Key Laboratory of the Ministry of Education in China on Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing, China.
Planta Med. 2010 Dec;76(17):1987-96. doi: 10.1055/s-0030-1250520. Epub 2010 Nov 3.
Chinese herbal medicines are often referred to as Chinese materia medica (CMM). Composite formulae containing mixtures of CMM are prescribed for treatment and prevention of diseases in the practice of traditional Chinese medicine (TCM). Some of the well-known CMM formulae (Fufang in Chinese) are manufactured and marketed as proprietary Chinese medicines (PCM). Quality assessment and assurance of these products are difficult; they are a challenging task. Mid-infrared spectroscopy, a classic molecular structure analysis method, has been innovatively applied in the quality control of TCM, and has gained significant impact and advancement in analytical fields. Infrared fingerprinting features appear particularly suitable for the identification of multicomponent matrices in samples whose chemical integrity has not been altered or destroyed because no extraction procedure is needed. This review summarizes and gives an overall view on the application of mid-infrared and two-dimensional correlation infrared (2D-IR) spectroscopy as well as chemometric techniques in the identification of CMM, investigation of TCM processing procedures, and analysis of herb extracts and preparations.
中草药通常被称为中药（CMM）。含有 CMM 混合物的复方方剂被用于中医（TCM）的疾病治疗和预防。一些著名的 CMM 方剂（中药复方）被制成并作为专利中药（PCM）销售。这些产品的质量评估和保证很困难，是一项具有挑战性的任务。中红外光谱作为一种经典的分子结构分析方法，已被创新性地应用于中药质量控制，并在分析领域取得了显著的影响和进展。因为不需要提取程序，所以红外指纹特征特别适合于识别其化学完整性未被改变或破坏的多组分矩阵的样品。本综述总结并全面概述了中红外和二维相关红外（2D-IR）光谱以及化学计量学技术在 CMM 识别、TCM 加工过程研究以及草药提取物和制剂分析中的应用。
