Krökki Olga, Bloigu Risto, Ansakorpi Hanna, Reunanen Mauri, Remes Anne M
Institute of Clinical Medicine, Neurology, University of Oulu, Oulu, Finland.
Medical Informatics Group, University of Oulu, Oulu, Finland.
Mult Scler Relat Disord. 2014 Jan;3(1):72-7. doi: 10.1016/j.msard.2013.06.006. Epub 2013 Jul 18.
There is increasing interest in the survival of multiple sclerosis (MS). MS itself may decrease life expectancy; however, several other comorbid diseases may also influence survival. We aimed to evaluate frequency of other neurological conditions and survival in the population-based Finnish Northern Ostrobothnia MS cohort.
The frequencies of neurological comorbid diseases and their associations with gender, clinical course, disability level (EDSS) and duration of MS were evaluated in population based cohort of 491 patients with clinically definite MS that was diagnosed between 1990 and 2010. The survival rate of the patients was also analysed.
One or more neurological comorbid disease was present in 17.1% of patients (n=84). The prevalence of epilepsy in MS patients was 4.7%, which is greater than that in the general population. Migraine was significantly more common in women with a benign MS course when compared to other types of MS (p=0.046). A significant association between peripheral nervous system disorders and primary progressive MS was found (p=0.027). The 21-year survival rate from time of diagnosis was 90.5%. Stroke decreased the 21-year survival rate of the patients (p=0.003). An association between stroke prevalence and the duration of MS disease was also detected (p=0.023).
This is the first report of multifaceted neurological comorbidities in MS patients. Neurological comorbidity is rather common in MS. However, only the prevalence of epilepsy was increased in MS patients compared to the general population. An association between peripheral nervous system disorders and primary progressive MS was also found. The 21-year survival rate was greater in the present population based cohort compared in other studies, but stroke seems to decrease the survival rate in MS patients.
人们对多发性硬化症（MS）患者的生存率越来越感兴趣。MS本身可能会缩短预期寿命；然而，其他几种合并症也可能影响生存率。我们旨在评估芬兰北博滕地区以人群为基础的MS队列中其他神经系统疾病的发生率及生存率。
在1990年至2010年间确诊的491例临床确诊MS患者的人群队列中，评估神经合并症的发生率及其与性别、临床病程、残疾程度（扩展残疾状态量表，EDSS）和MS病程的相关性。同时分析患者的生存率。
17.1%的患者（n = 84）存在一种或多种神经合并症。MS患者中癫痫的患病率为4.7%，高于普通人群。与其他类型的MS相比，良性病程的女性MS患者偏头痛明显更常见（p = 0.046）。发现周围神经系统疾病与原发进展型MS之间存在显著关联（p = 0.027）。从诊断时起的21年生存率为90.5%。中风降低了患者的21年生存率（p = 0.003）。还检测到中风患病率与MS病程之间的关联（p = 0.023）。
这是关于MS患者多方面神经合并症的首份报告。神经合并症在MS中相当常见。然而，与普通人群相比，仅MS患者中癫痫的患病率有所增加。还发现周围神经系统疾病与原发进展型MS之间存在关联。与其他研究相比，本以人群为基础的队列中的21年生存率更高，但中风似乎会降低MS患者的生存率。
