Nuyen Jasper, Schellevis François G, Satariano William A, Spreeuwenberg Peter M, Birkner Merrill D, van den Bos Geertrudis A M, Groenewegen Peter P
NIVEL (Netherlands Institute for Health Services Research), Otterstraat 118124, P.O. Box 1568, 3500 BN, Utrecht, The Netherlands.
J Clin Epidemiol. 2006 Dec;59(12):1274-84. doi: 10.1016/j.jclinepi.2006.01.005. Epub 2006 May 30.
To comprehensively examine comorbidity in unselected cohorts of patients with depression, stroke, multiple sclerosis (MS), Parkinson's disease/parkinsonism (PD/PKM), dementia, migraine, and epilepsy.
This cross-sectional study used morbidity data recorded by Dutch general practitioners. Index disease cohort sizes ranged from 241 patients with MS to 6,641 patients with lifetime depression. Thirty somatic and seven psychiatric disease categories were examined to determine whether they were comorbid with the index diseases by performing comparisons with age- and gender-matched control cohorts. Identified comorbidities were classified as either "possible" or "highly probable" comorbidity.
An extensive range of 26 disease categories was found to be comorbid with lifetime depression. The comorbidity profile of stroke was also wide, including 21 disease categories. The comorbidity patterns of migraine and epilepsy comprised each 11 disease categories. Those concerning MS, PD/PKM, and dementia included a small number of disease categories.
This study provides comprehensive knowledge of the occurrence of somatic and psychiatric comorbidity in general populations of patients with depression, stroke, MS, PD/PKM, dementia, migraine, and epilepsy. The implications of the findings for clinical practice and research are discussed.
全面研究未经过筛选的抑郁症、中风、多发性硬化症（MS）、帕金森病/帕金森综合征（PD/PKM）、痴呆症、偏头痛和癫痫患者队列中的共病情况。
这项横断面研究使用了荷兰全科医生记录的发病数据。索引疾病队列规模从241例MS患者到6641例终生患抑郁症的患者不等。通过与年龄和性别匹配的对照队列进行比较，对30种躯体疾病和7种精神疾病类别进行检查，以确定它们是否与索引疾病共病。确定的共病被分类为“可能”或“极有可能”共病。
发现有26种疾病类别与终生抑郁症共病。中风的共病情况也很广泛，包括21种疾病类别。偏头痛和癫痫的共病模式各包括11种疾病类别。与MS、PD/PKM和痴呆症相关的共病包括少数疾病类别。
本研究提供了关于抑郁症、中风、MS、PD/PKM、痴呆症、偏头痛和癫痫患者普通人群中躯体和精神共病发生情况的全面知识。讨论了研究结果对临床实践和研究的意义。
