Fawwad Asher, Siddiqui Iftikhar Ahmed, Zeeshan Nimra Fatima, Shahid Syed Muhammad, Basit Abdul
Asher Fawwad, M.Phil. Assistant Professor, Senior Research Scientist, Research Department, Baqai Institute of Diabetology and Endocrinology, Baqai Medical University, Plot No. 1-2, II-B, Nazimabad No2, Karachi-74600, Pakistan.
Iftikhar Ahmed Siddiqui, PhD. Chairman& Professor of Biochemistry, Department of Biochemistry, Baqai Medical University, Pakistan.
Pak J Med Sci. 2015 Jan-Feb;31(1):140-5. doi: 10.12669/pjms.311.6524.
To determine the association of SNP in FTO gene, rs9939609, with Metabolic Syndrome (MS) in type 2 diabetic subjects at a tertiary care unit of Karachi, Pakistan.
We genotyped FTO rs9939609 SNP in 296 patients with type 2 diabetes from the Out Patient Department (OPD) of Baqai Institute of Diabetology and Endocrinology (BIDE). MS was defined on the basis of International Diabetes Federation (IDF) and National Cholesterol Education program (NCEP) criterion. Association between the rs9939609 SNP and MS was tested through chi-square and Z-tests by using odds ratio (OR) with 95% confidence intervals.
The frequency of MS as defined by IDF criterion was significantly higher in female subjects as compared to male subjects (p= 0.006). Carriers of ≥ 1 copy of the rs9939609 A allele were significantly more likely to had MS (69.6%) than non-carriers (30.4%), corresponding to a carrier odds ratio (OR) of 0.52 (95% confidence interval [CI] (0.29-0.93), with a similar trend for the ATP III-defined MS."A" allele carriers under dominant model, carry all the criterion of MS more significantly as compared to non-carriers.
The FTO rs9939609 SNP was associated with an increased risk for Metabolic Syndrome in type 2 diabetic populations at a tertiary care unit of Karachi, Pakistan.
在巴基斯坦卡拉奇一家三级医疗机构中，确定FTO基因单核苷酸多态性（SNP）rs9939609与2型糖尿病患者代谢综合征（MS）之间的关联。
我们对巴凯糖尿病与内分泌研究所（BIDE）门诊部（OPD）的296例2型糖尿病患者的FTO rs9939609 SNP进行了基因分型。MS根据国际糖尿病联盟（IDF）和美国国家胆固醇教育计划（NCEP）标准进行定义。通过卡方检验和Z检验，使用比值比（OR）及95%置信区间来检测rs9939609 SNP与MS之间的关联。
根据IDF标准定义的MS在女性受试者中的发生率显著高于男性受试者（p = 0.006）。rs9939609 A等位基因≥1拷贝的携带者患MS的可能性（69.6%）显著高于非携带者（30.4%），携带者比值比（OR）为0.52（95%置信区间[CI]为0.29 - 0.93），ATP III定义的MS也有类似趋势。在显性模型下，“A”等位基因携带者比非携带者更显著地符合所有MS标准。
在巴基斯坦卡拉奇一家三级医疗机构中，FTO rs9939609 SNP与2型糖尿病人群代谢综合征风险增加有关。
