College of Medicine, Research Institute for Medical and Health Sciences, University of Sharjah, United Arab Emirates; College of Medicine, Cairo University, Egypt.
College of Medicine, Research Institute for Medical and Health Sciences, University of Sharjah, United Arab Emirates.
Gene. 2019 Jan 10;681:93-98. doi: 10.1016/j.gene.2018.09.053. Epub 2018 Sep 29.
Fat mass and obesity-associated protein gene variants have shown diverse influence on body weight and metabolism across different populations. Overweight, obesity and metabolic syndrome are multifactorial major health problems in the UAE and worldwide. Insulin resistance represents the link between overweight and development of metabolic syndrome and type 2 diabetes mellitus. We investigated two (FTO) variants in Emirati population, in relation to insulin resistance and different parameters of metabolic syndrome.
We recruited 259 Emiratis through the UAE National Diabetes and Lifestyle Project. Ethical approval was obtained. Besides basic data collection, venous blood samples were collected. Fasting blood glucose, Lipid profile, and insulin levels were measured. Genotyping for (FTO) rs9939609 (A>T) and rs9930506 (G>A) were performed using real time-PCR. Insulin resistance were identified using HOMA2-IR calculation; with a cut-off point of 1.4 for female and 1.18 for male subjects.
The study included 259 Emiratis (age range 30-53 years, mean 41.76 years, 54.4% females), 24.5% are diabetic and 30.8% are hypertensive, with body mass index of 28.4 ± 5.9 and 28.7 ± 5.7 kg/m in female and male subjects, respectively. Homozygous A of rs9939609 showed significantly higher fasting glucose compared to other genotypes (p = 0.04) with a trend of higher insulin level and HOMA-2IR. The A/A diabetic patients (n = 13) showed significantly higher insulin levels compared to other genotypes. G allele of rs9930506 showed a trend of higher fasting glucose and HOMA-2IR, but lower insulin level and HbA1c. No association of genotypes was detected with other components of metabolic syndrome.
There is an association of FTO rs9939609 A/A genotype and impaired fasting glucose and insulin resistance. Homozygous A genotype diabetic patients may be more vulnerable to blood glucose fluctuation. Focused genotyping can help the health care providers to identify high risk groups of both normal population and diabetic patients to intervene accordingly.
脂肪量和肥胖相关蛋白基因变异在不同人群中对体重和代谢有不同的影响。超重、肥胖和代谢综合征是阿联酋和全球的多因素重大健康问题。胰岛素抵抗代表了超重与代谢综合征和 2 型糖尿病发展之间的联系。我们研究了阿联酋人群中两个（FTO）变体与胰岛素抵抗和代谢综合征的不同参数的关系。
我们通过阿联酋国家糖尿病和生活方式项目招募了 259 名阿联酋人。获得了伦理批准。除了基本数据收集外，还采集了静脉血样。测量空腹血糖、血脂谱和胰岛素水平。使用实时 PCR 对（FTO）rs9939609（A>T）和 rs9930506（G>A）进行基因分型。使用 HOMA2-IR 计算来确定胰岛素抵抗；女性的截断值为 1.4，男性为 1.18。
该研究包括 259 名阿联酋人（年龄 30-53 岁，平均 41.76 岁，54.4%为女性），24.5%为糖尿病患者，30.8%为高血压患者，女性和男性的体重指数分别为 28.4±5.9 和 28.7±5.7kg/m。rs9939609 的纯合 AA 型与其他基因型相比，空腹血糖明显升高（p=0.04），胰岛素水平和 HOMA-2IR 呈升高趋势。A/A 型糖尿病患者（n=13）的胰岛素水平明显高于其他基因型。rs9930506 的 G 等位基因与空腹血糖和 HOMA-2IR 呈升高趋势，但胰岛素水平和 HbA1c 降低。未检测到基因型与代谢综合征的其他成分有关。
FTO rs9939609 A/A 基因型与空腹血糖受损和胰岛素抵抗有关。纯合 AA 基因型的糖尿病患者可能更容易出现血糖波动。有针对性的基因分型可以帮助医疗保健提供者识别正常人群和糖尿病患者的高危人群，以便进行相应的干预。
