Ravishankar N
Department of Pediatrics, Pediatric Intensive Care Unit, Max Superspecialty Hospital, Saket, New Delhi, India.
J Pediatr Neurosci. 2015 Jan-Mar;10(1):67-9. doi: 10.4103/1817-1745.154359.
Guillain-Barre syndrome (GBS) is a common cause of acute flaccid paralysis in children. Axonal variants of this disease are rare, and frequently life-threatening or debilitating. The course and outcome of a 17-month-old child with acute flaccid paralysis including severe respiratory involvement are presented. GBS was suspected. Nerve conduction studies demonstrated acute motor-sensory axonal neuropathy including both phrenic nerves. The difficulties with the diagnosis and management of this severe and life-threatening condition are discussed. Significant morbidity is also highlighted. Axonal variants of GBS although rare cause significant morbidity in children. Diagnosis relies solely on accurate neurophysiologic testing and is important because the available treatment options for GBS are frequently ineffective in these variants.
吉兰-巴雷综合征（GBS）是儿童急性弛缓性麻痹的常见病因。该疾病的轴索性变异型较为罕见，且常危及生命或导致身体衰弱。本文介绍了一名17个月大患有急性弛缓性麻痹（包括严重呼吸受累）患儿的病程及转归。怀疑为GBS。神经传导研究显示为急性运动感觉轴索性神经病，累及双侧膈神经。文中讨论了这种严重且危及生命疾病的诊断和管理难点。还强调了显著的发病率。GBS的轴索性变异型虽罕见，但在儿童中会导致显著的发病率。诊断仅依靠准确的神经生理学检测，这很重要，因为GBS现有的治疗方案对这些变异型往往无效。
