Opaleye Oluyinka Oladele, Igboama Magdalene C, Ojo Johnson Adeyemi, Odewale Gbolabo
a Department of Medical Microbiology and Parasitology , College of Health Sciences, Ladoke Akintola University of Technology , Osogbo , Nigeria.
J Immunoassay Immunochem. 2016;37(1):29-42. doi: 10.1080/15321819.2015.1040160.
Sexually transmitted infections (STIs) are major public health challenge especially in developing countries. This study was designed to determine the prevalence of Hepatitis B virus (HBV), Hepatitis C Virus (HCV), Human immunodeficiency virus (HIV), and Human T-cell lymphotropic Virus type I (HTLV-I) among pregnant women attending antenatal clinic, in Ladoke Akintola University Teaching Hospital, Osogbo, and South-Western Nigeria. One hundred and eighty two randomly selected pregnant women were screened for HBsAg, anti-HCV, anti-HIV and HTLV-1 IgM antibodies using commercially available ELISA kit. Of the 182 blood samples of pregnant women screened whose age ranged from 15-49 years, 13 (7.1%), 5 (2.7%), 9 (4.9%), and 44 (24.2%) were positive for HBsAg, anti-HCV, anti-HIV, and HTLV-1 IgM antibodies, respectively. The co-infection rate of 0.5% was obtained for HBV/HCV, HBV/HIV, HIV/HTLV-1, and HCV/HTLV-1 while 1.1% and 0% was recorded for HBV/HTLV-1 and HCV/HIV co-infections, respectively. Expected risk factors such as history of surgery, circumcision, tattooing and incision showed no significant association with any of the viral STIs (P > 0.05). This study shows that there is the need for a comprehensive screening of all pregnant women for HBsAg, anti-HCV, anti-HIV and HTLV-1 to prevent mother to child transmission of these viral infections and its attending consequences.
性传播感染（STIs）是一项重大的公共卫生挑战，在发展中国家尤为如此。本研究旨在确定在尼日利亚西南部奥索博的拉多克·阿金托拉大学教学医院产前门诊就诊的孕妇中，乙型肝炎病毒（HBV）、丙型肝炎病毒（HCV）、人类免疫缺陷病毒（HIV）和人类嗜T淋巴细胞病毒I型（HTLV-I）的感染率。使用市售酶联免疫吸附测定（ELISA）试剂盒，对182名随机选择的孕妇进行了HBsAg、抗HCV、抗HIV和HTLV-1 IgM抗体筛查。在182份年龄在15至49岁之间的孕妇血液样本中，HBsAg、抗HCV、抗HIV和HTLV-1 IgM抗体阳性的分别有13例（7.1%）、5例（2.7%）、9例（4.9%）和44例（24.2%）。HBV/HCV、HBV/HIV、HIV/HTLV-1和HCV/HTLV-1的合并感染率为0.5%，而HBV/HTLV-1和HCV/HIV合并感染率分别为1.1%和0%。手术史、包皮环切术、纹身和切口等预期风险因素与任何一种病毒性性传播感染均无显著关联（P>0.05）。本研究表明，有必要对所有孕妇进行HBsAg、抗HCV、抗HIV和HTLV-1的全面筛查，以预防这些病毒感染的母婴传播及其相关后果。
