Loiselle Kristin A, Gutierrez-Colina Ana M, Eaton Cyd K, Simons Laura E, Devine Katie A, Mee Laura L, Blount Ronald L
Division of Behavioral Medicine and Clinical Psychology, Center for Adherence and Self-Management, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Pediatr Transplant. 2015 Jun;19(4):428-35. doi: 10.1111/petr.12480. Epub 2015 Apr 16.
Solid organ transplantation requires ongoing adherence to immunosuppressants and other medications. Although adolescence is a risk factor for poor medication-taking, little is known about the patterns of adherence within individuals over time. This study aimed to examine the stability of adherence over time using three different assessment techniques. Sixty-six AYA transplant recipients and/or their caregiver completed interviews of adherence at baseline and at least one yr later. Serum immunosuppressant assay levels were collected via medical chart review. Non-adherence percentages based on AYA report, caregiver report, and bioassay did not differ from Time 1 to Time 2. However, correlations for these measures across time were non-significant. Further, the majority of AYAs shifted to a different adherence category from Time 1 to Time 2. Overall, these results demonstrate individual variability in non-adherence over the course of adolescence and young adulthood and highlight the importance of frequent assessment across time for solid organ transplant recipients.
实体器官移植需要持续服用免疫抑制剂和其他药物。尽管青春期是服药依从性差的一个风险因素，但对于个体随时间推移的依从模式却知之甚少。本研究旨在使用三种不同的评估技术来检验随时间推移依从性的稳定性。66名青少年和青年移植受者及/或其照顾者在基线时和至少一年后完成了依从性访谈。通过查阅病历收集血清免疫抑制剂检测水平。基于青少年报告、照顾者报告和生物检测的不依从百分比在时间1到时间2之间没有差异。然而，这些测量指标随时间的相关性并不显著。此外，从时间1到时间2，大多数青少年转变为不同的依从类别。总体而言，这些结果表明在青少年和青年期过程中不依从存在个体差异，并强调了对实体器官移植受者进行随时间频繁评估的重要性。
