Jung Sung-Hoon, Ahn Jae-Sook, Kim Yeo-Kyeoung, Kweon Sun-Seog, Min Jung-Joon, Bom Hee-Seung, Kim Hyeoung-Joon, Chae Yee Soo, Moon Joon Ho, Sohn Sang Kyun, Lee Sang Woo, Byun Byung Hyun, Do Young Rok, Lee Je-Jung, Yang Deok-Hwan
Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, 322 Seoyangro, Hwasun, Jeollanamdo, 519-763, Republic of Korea.
Department of preventive Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
BMC Cancer. 2015 Mar 28;15:198. doi: 10.1186/s12885-015-1193-1.
The role of interim PET/CT in peripheral T-cell lymphoma (PTCL) is less identified compared to other subtype of lymphoma. This study prospectively investigated the prognostic accuracy of sequential interim PET/CT using visual and quantitative assessment to determine whether it provided prognostic information for the treatment of PTCL.
Sixty-three patients with newly diagnosed PTCL were enrolled, and 59 patients underwent interim PET/CT after three or four courses of induction treatment. The response of interim PET/CT was assessed by three parameters: the Deauville five-point scale (5-PS), ΔSUVmax, and ΔMTV2.5.
Over a median follow up of 40.3 months, each assessment of interim PET/CT using the 5-PS, ΔSUVmax, and ΔMTV2.5 had predictive value for progression-free survival. To increase the predictive accuracy of interim PET/CT, we divided patients into three groups according to the sum of scores for three adverse responses based on the visual, SUV-based and MTV-based assessment: favorable, intermediate, and poor responder. The clinical outcome of patients in the favorable group was significantly superior to patients in the poor or intermediate group.
Visual, quantitative SUV-based, and MTV-based assessment in interim PET/CT are valuable for early treatment response assessment in patients with PTCL, and the combined approach using the three parameters was more efficient in discriminating between patients with different survival outcomes compared with single-parameter assessment.
NCT01470066 .
与其他淋巴瘤亚型相比，中期PET/CT在外周T细胞淋巴瘤（PTCL）中的作用尚不明确。本研究前瞻性地调查了序贯中期PET/CT使用视觉和定量评估的预后准确性，以确定其是否能为PTCL的治疗提供预后信息。
纳入63例新诊断的PTCL患者，59例患者在三或四个疗程诱导治疗后接受中期PET/CT检查。中期PET/CT的反应通过三个参数评估：迪厄多内五点量表（5-PS）、ΔSUVmax和ΔMTV2.5。
在中位随访40.3个月期间，使用5-PS、ΔSUVmax和ΔMTV2.5对中期PET/CT进行的每次评估对无进展生存期均有预测价值。为提高中期PET/CT的预测准确性，我们根据基于视觉、基于SUV和基于MTV评估的三种不良反应得分总和将患者分为三组：良好反应者、中等反应者和不良反应者。良好反应组患者的临床结局显著优于不良或中等反应组患者。
中期PET/CT中的视觉、基于定量SUV和基于MTV的评估对PTCL患者的早期治疗反应评估有价值，与单参数评估相比，使用这三个参数的联合方法在区分不同生存结局的患者方面更有效。
NCT01470066
