Thompson A C, Nolan A, Lamey P J
Department of Otolarygology, Victoria Infirmary, Langside, Glasgow.
Scott Med J. 1989 Oct;34(5):531-2. doi: 10.1177/003693308903400509.
A double-blind crossover study is described of the effect of beclomethasone dipropionate aerosol spray in patients with recurrent (minor) aphthous oral ulceration. Patients included in the study had normal haematological parameters of haemoglobin, ferritin, vitamin B12 and corrected whole blood folate. The design of the study incorporated a washout period and duration of effect was evaluated up to six months. Beclomethasone dipropionate significantly reduced ulcer pain severity and ulcer frequency, but had no significant effect on recurrence of oral ulceration. The preparation was associated with a high patient compliance and has benefit in relieving symptoms in patients with recurrent minor aphthous ulceration.
本文描述了一项关于二丙酸倍氯米松气雾剂对复发性（轻度）阿弗他口腔溃疡患者疗效的双盲交叉研究。纳入该研究的患者血红蛋白、铁蛋白、维生素B12及校正全血叶酸的血液学参数均正常。研究设计包括洗脱期，并对长达六个月的疗效持续时间进行了评估。二丙酸倍氯米松可显著降低溃疡疼痛严重程度和溃疡发作频率，但对口腔溃疡复发无显著影响。该制剂患者依从性高，对缓解复发性轻度阿弗他溃疡患者的症状有益。
