Graykowski E A, Kingman A
J Oral Pathol. 1978;7(6):376-82. doi: 10.1111/j.1600-0714.1978.tb01605.x.
A double-blind trial of a tetracycline suspension was carried out in 25 patients with recurrent aphthous oral ulcerations. A combined topical-systemic treatment procedure was used. Both the placebo and tetracycline group experienced reductions in ulcer incidence during the treatment period, whereas only the tetracycline group showed significant reductions in ulcer duration, size, and pain. Tetracylcine treatment apparently alters the severity of the ulcer, but does not appear to affect those factors responsible for recurrences. The side effects recorded in patients taking tetracycline were comparable to those in patients on placebo.
对25例复发性口腔溃疡患者进行了四环素混悬液的双盲试验。采用了局部与全身联合治疗方法。在治疗期间，安慰剂组和四环素组的溃疡发生率均有所降低，然而只有四环素组的溃疡持续时间、大小和疼痛有显著降低。四环素治疗明显改变了溃疡的严重程度，但似乎并未影响导致复发的那些因素。服用四环素患者记录的副作用与服用安慰剂患者的副作用相当。
