睫状神经营养因子（CNTF）的纯化、克隆及表达
Purification, cloning, and expression of ciliary neurotrophic factor (CNTF).
作者信息
Lin L F, Mismer D, Lile J D, Armes L G, Butler E T, Vannice J L, Collins F
机构信息
Protein Chemistry Group, Synergen, Inc., Boulder, CO 80301.
出版信息
Science. 1989 Nov 24;246(4933):1023-5. doi: 10.1126/science.2587985.
Ciliary neurotrophic factor (CNTF) is one of a small number of proteins with neurotrophic activities distinct from nerve growth factor (NGF). CNTF has now been purified and cloned and the primary structure of CNTF from rabbit sciatic nerve has been determined. Biologically active CNTF has been transiently expressed from a rabbit complementary DNA clone. CNTF is a neural effector without significant sequence homologies to any previously reported protein.
睫状神经营养因子（CNTF）是少数具有不同于神经生长因子（NGF）的神经营养活性的蛋白质之一。目前，CNTF已被纯化和克隆，兔坐骨神经中CNTF的一级结构也已确定。具有生物活性的CNTF已从兔互补DNA克隆中瞬时表达。CNTF是一种神经效应分子，与此前报道的任何蛋白质均无明显的序列同源性。
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