白细胞介素-6 家族细胞因子的历史概述。
Historical overview of the interleukin-6 family cytokine.
机构信息
Department of Immune Regulation, Immunology Frontier Research Center, Osaka University, Osaka, Japan.
Department of Advanced Clinical and Translational Immunology, Graduate School of Medicine, Osaka University, Osaka, Japan.
出版信息
J Exp Med. 2020 May 4;217(5). doi: 10.1084/jem.20190347.
Interleukin-6 (IL-6) has been identified as a 26-kD secreted protein that stimulates B cells to produce antibodies. Later, IL-6 was revealed to have various functions that overlap with other IL-6 family cytokines and use the common IL-6 signal transducer gp130. IL-6 stimulates cells through multiple pathways, using both membrane and soluble IL-6 receptors. As indicated by the expanding market for IL-6 inhibitors, it has become a primary therapeutic target among IL-6 family cytokines. Here, we revisit the discovery of IL-6; discuss insights regarding the roles of this family of cytokines; and highlight recent advances in our understanding of regulation of IL-6 expression.
白细胞介素 6（IL-6）已被鉴定为一种 26kDa 的分泌蛋白，可刺激 B 细胞产生抗体。后来，IL-6 被揭示具有与其他白细胞介素 6 家族细胞因子重叠的多种功能，并使用共同的白细胞介素 6 信号转导蛋白 gp130。IL-6 通过多种途径刺激细胞，既使用膜结合型白细胞介素 6 受体，也使用可溶性白细胞介素 6 受体。正如白细胞介素 6 抑制剂不断扩大的市场所表明的那样，它已成为白细胞介素 6 家族细胞因子的主要治疗靶点。在这里，我们重新审视了白细胞介素 6 的发现；讨论了关于这个细胞因子家族作用的新见解；并强调了我们对白细胞介素 6 表达调控的理解的最新进展。
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