Agar E
Department of Physiology, Faculty of Medicine, University of Ondokuz Mayis, Samsun, Turkey.
Acta Neurol Scand. 2015 Dec;132(6):371-80. doi: 10.1111/ane.12411. Epub 2015 Apr 15.
Cannabinoids exert a neuroprotective influence on some neurological diseases, including Alzheimer's, Parkinson's, Huntington's, multiple sclerosis and epilepsy. Synthetic cannabinoid receptor agonists/antagonists or compounds can provide symptom relief or control the progression of neurological diseases. However, the molecular mechanism and the effectiveness of these agents in controlling the progression of most of these diseases remain unclear. Cannabinoids may exert effects via a number of mechanisms and interactions with neurotransmitters, neurotropic factors and neuropeptides. Leptin is a peptide hormone involved in the regulation of food intake and energy balance via its actions on specific hypothalamic nuclei. Leptin receptors are widely expressed throughout the brain, especially in the hippocampus, basal ganglia, cortex and cerebellum. Leptin has also shown neuroprotective properties in a number of neurological disorders, such as Parkinson's and Alzheimer's. Therefore, cannabinoid and leptin hold therapeutic potential for neurological diseases. Further elucidation of the molecular mechanisms underlying the effects on these agents may lead to the development of new therapeutic strategies for the treatment of neurological disorders.
大麻素对一些神经系统疾病具有神经保护作用，包括阿尔茨海默病、帕金森病、亨廷顿病、多发性硬化症和癫痫。合成大麻素受体激动剂/拮抗剂或化合物可缓解症状或控制神经系统疾病的进展。然而，这些药物在控制大多数此类疾病进展方面的分子机制和有效性仍不清楚。大麻素可能通过多种机制以及与神经递质、神经营养因子和神经肽的相互作用发挥作用。瘦素是一种肽类激素，通过作用于特定的下丘脑核来参与食物摄入和能量平衡的调节。瘦素受体在整个大脑中广泛表达，尤其是在海马体、基底神经节、皮层和小脑中。瘦素在一些神经系统疾病，如帕金森病和阿尔茨海默病中也显示出神经保护特性。因此，大麻素和瘦素对神经系统疾病具有治疗潜力。进一步阐明这些药物作用的分子机制可能会导致开发治疗神经系统疾病的新治疗策略。
