Lu Yan, Anderson Hope D
a College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, 750 McDermot Avenue, Winnipeg, MB R3E 0T5, Canada.
b Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Hospital Research Centre, 351 Taché Avenue, Winnipeg, MB R2H 2A6, Canada.
Can J Physiol Pharmacol. 2017 Apr;95(4):311-327. doi: 10.1139/cjpp-2016-0346. Epub 2017 Mar 6.
Cannabis sativa has long been used for medicinal purposes. To improve safety and efficacy, compounds from C. sativa were purified or synthesized and named under an umbrella group as cannabinoids. Currently, several cannabinoids may be prescribed in Canada for a variety of indications such as nausea and pain. More recently, an increasing number of reports suggest other salutary effects associated with endogenous cannabinoid signaling including cardioprotection. The therapeutic potential of cannabinoids is therefore extended; however, evidence is limited and mechanisms remain unclear. In addition, the use of cannabinoids clinically has been hindered due to pronounced psychoactive side effects. This review provides an overview on the endocannabinoid system, including known physiological roles, and conditions in which cannabinoid receptor signaling has been implicated.
长期以来，大麻一直被用于医疗目的。为了提高安全性和有效性，从大麻中提取或合成的化合物被提纯，并在一个统称下命名为大麻素。目前，在加拿大，几种大麻素可用于治疗多种病症，如恶心和疼痛。最近，越来越多的报告表明，内源性大麻素信号传导还具有其他有益作用，包括心脏保护作用。因此，大麻素的治疗潜力得到了扩展；然而，证据有限，其作用机制仍不清楚。此外，大麻素在临床上的应用因明显的精神活性副作用而受到阻碍。本综述概述了内源性大麻素系统，包括已知的生理作用，以及与大麻素受体信号传导有关的病症。
