The Keenan Research Centre for Biomedical Science of St. Michael's, Toronto, Ontario, Canada; Department of Anesthesia, University of Toronto, Ontario, Canada.
The Keenan Research Centre for Biomedical Science of St. Michael's, Toronto, Ontario, Canada; German Heart Institute Berlin, Germany; Institute of Physiology, Charité-Universitätsmedizin Berlin, Germany; Department of Surgery, University of Toronto, Ontario, Canada; Department of Physiology, University of Toronto, Ontario,Canada.
Compr Physiol. 2015 Apr;5(2):531-59. doi: 10.1002/cphy.c140024.
The pulmonary endothelium represents a heterogeneous cell monolayer covering the luminal surface of the entire lung vasculature. As such, this cell layer lies at a critical interface between the blood, airways, and lung parenchyma, and must act as a selective barrier between these diverse compartments. Lung endothelial cells are able to produce and secrete mediators, display surface receptor, and cellular adhesion molecules, and metabolize circulating hormones to influence vasomotor tone, both local and systemic inflammation, and coagulation functions. In this review, we will explore the role of the pulmonary endothelium in each of these systems, highlighting key regulatory functions of the pulmonary endothelial cell, as well as novel aspects of the pulmonary endothelium in contrast to the systemic cell type. The interactions between pulmonary endothelial cells and both leukocytes and platelets will be discussed in detail, and wherever possible, elements of endothelial control over physiological and pathophysiological processes will be examined.
肺内皮细胞代表着一种异质的细胞单层，覆盖着整个肺血管系统的腔面。因此，这个细胞层位于血液、气道和肺实质之间的关键界面上，必须作为这些不同隔室之间的选择性屏障。肺内皮细胞能够产生和分泌介质，表达表面受体和细胞黏附分子，并代谢循环激素，以影响血管舒缩张力、局部和全身炎症以及凝血功能。在这篇综述中，我们将探讨肺内皮细胞在这些系统中的作用，强调肺内皮细胞的关键调节功能，以及肺内皮细胞与全身细胞类型相比的新方面。我们将详细讨论肺内皮细胞与白细胞和血小板之间的相互作用，并在可能的情况下，研究内皮细胞对生理和病理生理过程的控制作用。
