Mathew R, Altura B M
New York Medical College, Valhalla 10595.
Microcirc Endothelium Lymphatics. 1990 Aug-Oct;6(4-5):211-52.
The lungs provide not only respiratory function, but also are involved in metabolism and maintaining homeostasis. The lungs receive the entire cardiac output, circulating blood cells and hormones. The metabolically active vascular endothelial cell lining participates in degrading and synthesizing various hormones and vasoactive substances which affect the pulmonary as well as systemic circulation. The normal state is maintained through complex interaction of the circulating hormones, maturation of the system, the physiological state of the lung cells and metabolism. Any noxious stimulus can disrupt this delicate balance and adversely affect the metabolism of various substances, thus producing an abnormal state. In this review, some of these factors including therapeutic implications are discussed.
肺不仅具有呼吸功能，还参与新陈代谢并维持体内平衡。肺接受全部的心输出量，使血细胞和激素循环。具有代谢活性的血管内皮细胞参与多种激素和血管活性物质的降解与合成，这些物质会影响肺循环和体循环。通过循环激素、系统成熟度、肺细胞的生理状态和新陈代谢之间的复杂相互作用来维持正常状态。任何有害刺激都可能破坏这种微妙的平衡，并对各种物质的代谢产生不利影响，从而产生异常状态。在本综述中，将讨论其中一些因素，包括治疗意义。
