De Mello Walmor C
School of Medicine, Medical Sciences Campus, UPR, San Juan, PR 00936, USA.
Peptides. 2015 Oct;72:57-60. doi: 10.1016/j.peptides.2015.04.001. Epub 2015 Apr 13.
The influence of intracellular angiotensin II (Ang II) on the process of chemical communication and metabolic cooperation between cardiac cells is discussed. Emphasis is given to the influence of pathological conditions like heart failure, myocardial ischemia or hyperglycemia on the activation of the intracrine renin angiotensin aldosterone system (RAAS) and its consequence for the metabolic cooperation between heart cells. Furthermore, the influence of high glucose on the process of chemical communication was described as well as its implication for the failing and diabetic heart. The major conclusion is that the activation of the intracrine renin angiotensin induced by heart failure, hyperglycemia, aldosterone or myocardial ischemia generates metabolic imbalance in the heart with serious consequences for the cardiac function.
本文讨论了细胞内血管紧张素II（Ang II）对心脏细胞间化学通讯和代谢协作过程的影响。重点阐述了心力衰竭、心肌缺血或高血糖等病理状况对内分泌肾素血管紧张素醛固酮系统（RAAS）激活的影响及其对心脏细胞间代谢协作的后果。此外，还描述了高血糖对化学通讯过程的影响及其对衰竭心脏和糖尿病心脏的意义。主要结论是，心力衰竭、高血糖、醛固酮或心肌缺血诱导的内分泌肾素血管紧张素激活会导致心脏代谢失衡，对心脏功能产生严重后果。
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