De Mello Walmor C
Department of Pharmacology, School of Medicine, Medical Sciences Campus, UPR, San Juan, PR 00936-5067, USA.
Regul Pept. 2011 Jan 17;166(1-3):9-14. doi: 10.1016/j.regpep.2010.10.003. Epub 2010 Oct 8.
The influence of angiotensin II (Ang II) on cardiac structural and electrophysiological remodeling was discussed including the novel concept that the renin angiotensin aldosterone is involved in the regulation heart cell volume. Particular attention was given to the role of Ang II AT1 receptors as mechanosensors which are activated by mechanic stretch independently of Ang II. These findings highly suggest that RAS inhibitors or AT1 receptor blockers have additional beneficial therapeutics effects by changing mechanical transduction. The influence of cell swelling on cell communication as well as the effect of Ang II on cell volume and the consequent activation of ionic channels and the generation of cardiac arrhythmias was reviewed. The discovery of ACE2 and its relevance to heart pathology was also discussed.
讨论了血管紧张素II(Ang II)对心脏结构和电生理重塑的影响,包括肾素血管紧张素醛固酮参与调节心脏细胞体积这一新概念。特别关注了Ang II AT1受体作为机械传感器的作用,该受体可被机械牵张独立于Ang II激活。这些发现强烈表明,RAS抑制剂或AT1受体阻滞剂通过改变机械转导具有额外的有益治疗作用。综述了细胞肿胀对细胞通讯的影响以及Ang II对细胞体积的影响,以及由此导致的离子通道激活和心律失常的发生。还讨论了ACE2的发现及其与心脏病理学的相关性。