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[抗氧化剂不足条件下α-生育酚和紫罗兰酮对大鼠肝脏微粒体膜物理结构的影响]

[The effect of alpha-tocopherol and ionol on the physical structure of the membranes of rat liver microsomes under conditions of antioxidant insufficiency].

作者信息

Gubskiĭ Iu I, Boldeskul A E, Primak R G, Zadorina O V

出版信息

Ukr Biokhim Zh (1978). 1989 Jul-Aug;61(4):94-9.

PMID:2588341
Abstract

Physiochemical conformity of the alpha-tocopherol interaction with hepatic microsomal membranes has been studied by means of fluorescent probes (pyrene and 1-anilinonaphthalene-8-sulphonate). The microsomal membrane microviscosity is shown to sharply decrease under conditions of the antioxidant deficiency with vitamin E expelled into animals normalizes microviscosity, but feebly influences the microsomal surface charge. Microcalorimetry has been used to establish that penetration of tocopherol into microsomal membranes was accompanied by the exothermic effect.

摘要

已通过荧光探针(芘和1-苯胺基萘-8-磺酸盐)研究了α-生育酚与肝微粒体膜相互作用的物理化学一致性。结果表明,在抗氧化剂缺乏的情况下,微粒体膜微粘度急剧下降,而将维生素E注入动物体内可使微粘度恢复正常,但对微粒体表面电荷的影响微弱。微量热法已用于确定生育酚渗透到微粒体膜中伴随着放热效应。

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1
[The effect of alpha-tocopherol and ionol on the physical structure of the membranes of rat liver microsomes under conditions of antioxidant insufficiency].[抗氧化剂不足条件下α-生育酚和紫罗兰酮对大鼠肝脏微粒体膜物理结构的影响]
Ukr Biokhim Zh (1978). 1989 Jul-Aug;61(4):94-9.
2
[Peroxide modification of membranes and isomorphic composition of cytochrome P-450 of rat liver microsomes during antioxidant deficiency].[抗氧化剂缺乏时大鼠肝微粒体膜的过氧化物修饰及细胞色素P-450的同构组成]
Ukr Biokhim Zh (1978). 1992 Jan-Feb;64(1):98-105.
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4
[The mechanisms of the antioxidant action of shielded phenols in biological membranes. The effects of 4-methyl-2,6-di-tert-butylphenol (ionol) derivatives on luminol-dependent chemiluminescence].[屏蔽酚类在生物膜中的抗氧化作用机制。4-甲基-2,6-二叔丁基苯酚(紫罗兰醇)衍生物对鲁米诺依赖性化学发光的影响]
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[Effectiveness of lipid peroxidation inhibition in biomembranes by antioxidants with and without hydrocarbon chains].[含或不含烃链的抗氧化剂对生物膜脂质过氧化的抑制作用]
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[Calcium transport in endoplasmic reticulum of the rat liver during lipid peroxidation].
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[Effect of tocopherol, its analogs and the antioxidant ionol on lipid peroxidation in vitro].[生育酚及其类似物与抗氧化剂紫罗兰酮对体外脂质过氧化的影响]
Ukr Biokhim Zh (1978). 1993 May-Jun;65(3):94-9.
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beta-Carotene and alpha-tocopherol are synergistic antioxidants.β-胡萝卜素和α-生育酚是协同抗氧化剂。
Arch Biochem Biophys. 1992 Aug 15;297(1):184-7. doi: 10.1016/0003-9861(92)90658-j.
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Effect of dietary antioxidants on the susceptibility to hepatic microsomal lipid peroxidation in the rat.膳食抗氧化剂对大鼠肝微粒体脂质过氧化易感性的影响。
Ann Nutr Metab. 1995;39(2):99-106. doi: 10.1159/000177849.
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Vopr Med Khim. 1988 Jul-Aug;34(4):81-5.