Yamamoto K, Fukuda N, Shiroi S, Shiotsuki Y, Nagata Y, Tani T, Sakai T
Department of Internal Medicine, Saga Medical University School of Medicine, Japan.
Ann Nutr Metab. 1995;39(2):99-106. doi: 10.1159/000177849.
The inhibitory effect of probucol on ferrous-iron-induced microsomal lipid peroxidation was compared to that of alpha-tocopherol and butylated hydroxytoluene (BHT). Male Wistar rats were fed with diets containing 1% probucol, 0.2% BHT or 0.1% alpha-tocopherol for 30 days. There were no effects of dietary antioxidants on growth parameters, although liver weight was significantly higher in the BHT-fed rats. Probucol reduced serum levels of total and free cholesterol, while BHT feeding increased the concentrations of serum thiobarbituric-acid-reactive substances, HDL cholesterol and hepatic phospholipid. alpha-Tocopherol had no effect on these parameters. Incorporation of both, probucol and alpha-tocopherol, decreased the susceptibility of microsomes to lipid peroxidation in vitro, while BHT incorporation increased hepatic microsomal lipid peroxidation. These results suggest the possible usefulness of probucol for treatment of both hypercholesterolemia and elevated hepatic microsomal lipid peroxidation, while alpha-tocopherol decreases only an elevated lipid peroxidation. BHT works as a prooxidant.
将普罗布考对亚铁离子诱导的微粒体脂质过氧化的抑制作用与α-生育酚和丁基羟基甲苯（BHT）的抑制作用进行了比较。给雄性Wistar大鼠喂食含1%普罗布考、0.2%BHT或0.1%α-生育酚的日粮30天。日粮中的抗氧化剂对生长参数没有影响，不过喂食BHT的大鼠肝脏重量显著更高。普罗布考降低了血清总胆固醇和游离胆固醇水平，而喂食BHT则增加了血清硫代巴比妥酸反应性物质、高密度脂蛋白胆固醇和肝磷脂的浓度。α-生育酚对这些参数没有影响。同时加入普罗布考和α-生育酚会降低微粒体在体外对脂质过氧化的敏感性，而加入BHT则会增加肝微粒体脂质过氧化。这些结果表明，普罗布考可能对治疗高胆固醇血症和肝微粒体脂质过氧化升高均有用，而α-生育酚仅能降低升高的脂质过氧化。BHT起到促氧化剂的作用。
