Jiang Dai-Xun, Lu Zhi-Song, Li Ge-Bin, Sun Sheng-Yong, Mu Xiang, Lee Peter, Chen Wu
Beijing Key Laboratory of Traditional Chinese Veterinary Medicine, Beijing University of Agriculture, Beijing, China.
Beijing Key Laboratory of Traditional Chinese Veterinary Medicine, Beijing University of Agriculture, Beijing, China ; Department of Veterinary Biochemistry, Nippon Veterinary and Life Science University, Musashino, Tokyo, Japan.
Neural Regen Res. 2015 Feb;10(2):237-43. doi: 10.4103/1673-5374.152377.
Most studies on spinal cord neuronal injury have focused on spinal cord tissue histology and the expression of nerve cell damage and repair-related genes. The importance of the microcirculation is often ignored in spinal cord injury and repair research. Therefore, in this study, we established a rat model of intervertebral disc extrusion by inserting a silica gel pad into the left ventral surface of T13. Electroacupuncture was used to stimulate the bilateral Zusanli point (ST36) and Neiting point (ST44) for 14 days. Compared with control animals, blood flow in the first lumbar vertebra (L1) was noticeably increased in rats given electroacupuncture. Microvessel density in the T13 segment of the spinal cord was increased significantly as well. The number of normal neurons was higher in the ventral horn of the spinal cord. In addition, vacuolation in the white matter was lessened. No obvious glial cell proliferation was visible. Furthermore, hindlimb motor function was improved significantly. Collectively, our results suggest that electroacupuncture can improve neuronal morphology and microcirculation, and promote the recovery of neurological functions in a rat model of intervertebral disc extrusion.
大多数关于脊髓神经元损伤的研究都集中在脊髓组织组织学以及神经细胞损伤和修复相关基因的表达上。在脊髓损伤和修复研究中，微循环的重要性常常被忽视。因此，在本研究中，我们通过将硅胶垫插入T13左侧腹面建立了大鼠椎间盘突出模型。采用电针刺激双侧足三里穴（ST36）和内庭穴（ST44），持续14天。与对照动物相比，接受电针治疗的大鼠第一腰椎（L1）的血流量明显增加。脊髓T13节段的微血管密度也显著增加。脊髓腹角正常神经元数量较多。此外，白质中的空泡化减轻。未见明显的胶质细胞增殖。此外，后肢运动功能明显改善。总的来说，我们的结果表明，电针可以改善神经元形态和微循环，并促进大鼠椎间盘突出模型中神经功能的恢复。
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