在1131名健康中年男性中，肱踝脉搏波速度与冠状动脉钙化有关。
Brachial-ankle pulse wave velocity is associated with coronary calcification among 1131 healthy middle-aged men.
作者信息
Vishnu Abhishek, Choo Jina, Wilcox Bradley, Hisamatsu Takashi, Barinas-Mitchell Emma J M, Fujiyoshi Akira, Mackey Rachel H, Kadota Aya, Ahuja Vasudha, Kadowaki Takashi, Edmundowicz Daniel, Miura Katsuyuki, Rodriguez Beatriz L, Kuller Lewis H, Shin Chol, Masaki Kamal, Ueshima Hirotsugu, Sekikawa Akira
机构信息
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, USA.
College of Nursing, Korea University, Ansan, South Korea.
出版信息
Int J Cardiol. 2015;189:67-72. doi: 10.1016/j.ijcard.2015.04.020. Epub 2015 Apr 3.
BACKGROUND
Brachial-ankle pulse wave velocity (baPWV) is a simple and reproducible measure of arterial stiffness and is extensively used to assess cardiovascular disease (CVD) risk in eastern Asia. We examined whether baPWV is associated with coronary atherosclerosis in an international study of healthy middle-aged men.
METHODS
A population-based sample of 1131 men aged 40-49 years was recruited - 257 Whites and 75 Blacks in Pittsburgh, US, 228 Japanese-Americans in Honolulu, US, 292 Japanese in Otsu, Japan, and 279 Koreans in Ansan, Korea. baPWV was measured with an automated waveform analyzer (VP2000, Omron) and atherosclerosis was examined as coronary artery calcification (CAC) by computed-tomography (GE-Imatron EBT scanner). Association of the presence of CAC (defined as ≥ 10 Agatston unit) was examined with continuous measure as well as with increasing quartiles of baPWV.
RESULTS
As compared to the lowest quartile of baPWV, the multivariable-adjusted odds ratio (95% Confidence Interval [CI]) for the presence of CAC in the combined sample was 1.70 (0.98, 2.94) for 2nd quartile, 1.88 (1.08, 3.28) for 3rd quartile, and 2.16 (1.19, 3.94) for 4th quartile (p-trend = 0.01). The odds for CAC increased by 19% per 100 cm/s increase (p < 0.01), or by 36% per standard-deviation increase (p < 0.01) in baPWV. Similar effect-sizes were observed in individual races, and were significant among Whites, Blacks and Koreans.
CONCLUSION
baPWV is cross-sectionally associated with CAC among healthy middle-aged men. The association was significant in Whites and Blacks in the US, and among Koreans. Longitudinal studies are needed to determine its CVD predictive ability.
背景
肱踝脉搏波速度（baPWV）是一种简单且可重复的动脉僵硬度测量指标，在东亚地区被广泛用于评估心血管疾病（CVD）风险。我们在一项针对健康中年男性的国际研究中，探讨了baPWV是否与冠状动脉粥样硬化相关。
方法
招募了一个基于人群的样本，共1131名年龄在40 - 49岁的男性——美国匹兹堡的257名白人和75名黑人、美国檀香山的228名日裔美国人、日本大津的292名日本人以及韩国安山的279名韩国人。使用自动波形分析仪（VP2000，欧姆龙）测量baPWV，并通过计算机断层扫描（GE-Imatron EBT扫描仪）将动脉粥样硬化检查为冠状动脉钙化（CAC）。对CAC（定义为≥10阿加斯顿单位）的存在与baPWV的连续测量值以及四分位数增加情况之间的关联进行了检查。
结果
与baPWV最低四分位数相比，在合并样本中，多变量调整后的CAC存在的比值比（95%置信区间[CI]）在第二四分位数为1.70（0.98，2.94），第三四分位数为1.88（1.08，3.28），第四四分位数为2.16（1.19，3.94）（p趋势 = 0.01）。baPWV每增加100 cm/s，CAC的比值增加19%（p < 0.01），或每增加一个标准差，比值增加36%（p < 0.01）。在各个种族中观察到了类似的效应大小，并且在白人、黑人和韩国人中具有显著性。
结论
在健康中年男性中，baPWV与CAC存在横断面关联。这种关联在美国的白人和黑人以及韩国人中具有显著性。需要进行纵向研究以确定其对CVD的预测能力。
Zotero 插件