神经导向蛋白的高表达增加急性髓系白血病细胞对化疗药物的敏感性。
High expression of neuroguidin increases the sensitivity of acute myeloid leukemia cells to chemotherapeutic drugs.
作者信息
Chen Kejun, Lü Shuqing, Cheng Hui, Tang Gusheng, Liu Min, Zhou Hong, Wang Jianmin
机构信息
Department of Hematology, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai, 200433, China.
出版信息
J Hematol Oncol. 2015 Feb 19;8:11. doi: 10.1186/s13045-015-0108-6.
Neuroguidin (NGDN) is a eukaryotic translation initiation factor 4E binding protein. The purpose of this study was to clarify the function of NGDN and its possible mechanism of action in human myeloid leukemia cells. Proliferation inhibition and apoptosis in NGDN over-expressing myeloid multidrug-resistant leukemia cells (K562/A02-NGDN) was significantly higher than in control K562/A02 cells following treatment with vincristine, etoposide, and epirubicin, indicating that NGDN over-expression can increase the sensitivity of multidrug-resistant leukemia cells to chemotherapeutic drugs. Furthermore, NGDN knock-down in K562/A02 cells resulted in the activation of multiple tumor-related signaling pathways, especially the mammalian target of rapamycin (mTOR) pathway.
神经导向蛋白（NGDN）是一种真核生物翻译起始因子4E结合蛋白。本研究的目的是阐明NGDN在人髓系白血病细胞中的功能及其可能的作用机制。在用长春新碱、依托泊苷和表柔比星处理后，过表达NGDN的髓系多药耐药白血病细胞（K562/A02-NGDN）的增殖抑制和凋亡明显高于对照K562/A02细胞，表明NGDN过表达可增加多药耐药白血病细胞对化疗药物的敏感性。此外，K562/A02细胞中NGDN的敲低导致多种肿瘤相关信号通路的激活，尤其是雷帕霉素靶蛋白（mTOR）通路。
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