Saritas Turgay, Kuppe Christoph, Moeller Marcus J
Division of Nephrology and Immunology, RWTH Aachen University, Aachen, Germany *Turgay Saritas and Christoph Kuppe contributed equally to the writing of this article.
Curr Opin Nephrol Hypertens. 2015 May;24(3):208-16. doi: 10.1097/MNH.0000000000000116.
At first sight, the glomerular filter appears like a problem that should be easily solved. The majority of researchers view the filter like an impermeable wall perforated by specialized and size-selective pores (pore model). However, the fact that this model is in conflict with many of the experimental findings suggests that it may not yet be complete.
In the more recent electrokinetic model, we have proposed including electrical effects (streaming potentials). The present review investigates how this can provide a relatively simple mechanistic explanation for the great majority of the so far unexplained characteristics of the filter, for example why the filter never clogs.
Understanding how the glomerular filter functions is a prerequisite to investigate the pathogenesis of proteinuric glomerular diseases and the link between glomerular proteinuria and cardiovascular disease.
乍一看，肾小球滤过器似乎是一个应该很容易解决的问题。大多数研究人员将滤过器视为一堵不可渗透的墙，上面有专门的、具有尺寸选择性的小孔（孔模型）。然而，该模型与许多实验结果相矛盾这一事实表明它可能还不完整。
在最近的电动模型中，我们提议纳入电效应（流动电位）。本综述探讨了这如何能为滤过器绝大多数迄今无法解释的特征提供一个相对简单的机制解释，例如为什么滤过器从不堵塞。
了解肾小球滤过器的功能是研究蛋白尿性肾小球疾病的发病机制以及肾小球蛋白尿与心血管疾病之间联系的先决条件。
