Zhan Han-xiang, Xu Jian-wei, Wang Lei, Zhang Guang-yong, Hu San-yuan
Department of General Surgery, Qilu hospital, Shandong University, No. 107, Wenhua West Road, Lixia District, Jinan, Shandong Province, 250012, China.
World J Surg Oncol. 2015 Mar 13;13:105. doi: 10.1186/s12957-015-0510-0.
The prognostic value of lymph node ratio (LNR) in pancreatic cancer remains controversial. In the current retrospective study, we assessed the value of LNR on predicting the survival of postoperative patients with pancreatic cancer.
Medical records of patients who underwent pancreatic resection for pancreatic cancer in the department of general surgery, Qilu Hospital, Shandong University were reviewed retrospectively. Demographic, clinicopathological, tumor-specific data, and histopathological reports were collected. Univariate and multivariate survival analyses were performed.
A total of 83 patients with pancreatic cancer were collected. The mean number of examined LN was 8.2 ± 6.1 (0 to 26). Differential degree (low) (P = 0.019, hazard ratio (HR) = 2.276, 95% confidence interval (CI): 1.171 to 4.424) and LNR >0.2 (P = 0.018, HR = 2.685, 95% CI: 1.253 to 5.756) were independent adverse prognostic factors according to the multivariate survival analysis.
Our study indicated that LNR >0.2 was an independent adverse prognostic factor for pancreatic cancer, which may provide important information for prognostic assessment.
淋巴结比率（LNR）在胰腺癌中的预后价值仍存在争议。在当前这项回顾性研究中，我们评估了LNR对预测胰腺癌术后患者生存情况的价值。
回顾性分析山东大学齐鲁医院普通外科接受胰腺癌胰腺切除术患者的病历。收集人口统计学、临床病理、肿瘤特异性数据以及组织病理学报告。进行单因素和多因素生存分析。
共收集到83例胰腺癌患者。检查的淋巴结平均数量为8.2±6.1（0至26个）。根据多因素生存分析，分化程度（低）（P = 0.019，风险比（HR）= 2.276，95%置信区间（CI）：1.171至4.424）和LNR>0.2（P = 0.018，HR = 2.685，95%CI：1.253至5.756）是独立的不良预后因素。
我们的研究表明，LNR>0.2是胰腺癌的独立不良预后因素，这可能为预后评估提供重要信息。
