Roughley Matthew J, Belcher John, Mallen Christian D, Roddy Edward
School of Medicine, Keele University, Keele, Staffordshire, ST5 5BG, UK.
School of Computing and Mathematics, Keele University, Keele, Staffordshire, ST5 5BG, UK.
Arthritis Res Ther. 2015 Apr 1;17(1):90. doi: 10.1186/s13075-015-0610-9.
To determine the prevalence of chronic kidney disease and nephrolithiasis in people with gout, and the association between gout and prevalent or incident chronic kidney disease and nephrolithiasis.
Systematic review and meta-analysis of epidemiological studies. Data sources; MEDLINE, EMBASE and CINAHL databases, hand-searched reference lists, citation history and contact with authors.
cohort, case-control or cross-sectional studies which examined the occurrence of chronic kidney disease or nephrolithiasis amongst adults with gout (with or without a non-gout comparator group) in primary care or general population samples. Prevalence and risk estimate meta-analyses were performed using a random-effects model.
Seventeen studies were included in the meta-analysis (chronic kidney disease n = 7, nephrolithiasis n = 8, both n = 2). Pooled prevalence estimates of chronic kidney disease stage ≥3 and self-reported lifetime nephrolithiasis in people with gout were 24% (95% confidence interval 19% to 28%) and 14% (95% CI 12% to 17%) respectively. Gout was associated with both chronic kidney disease (pooled adjusted odds ratio 2.41, 95% confidence interval 1.86 to 3.11) and self-reported lifetime nephrolithiasis (1.77, 1.43 to 2.19).
Chronic kidney disease and nephrolithiasis are commonly found amongst patients with gout. Gout is independently associated with both chronic kidney disease and nephrolithiasis. Patients with gout should be actively screened for chronic kidney disease and its consequences.
确定痛风患者中慢性肾脏病和肾结石的患病率,以及痛风与现患或新发慢性肾脏病和肾结石之间的关联。
对流行病学研究进行系统评价和荟萃分析。数据来源:MEDLINE、EMBASE和CINAHL数据库、手工检索参考文献列表、引用记录并与作者联系。
队列研究、病例对照研究或横断面研究,这些研究调查了初级保健或普通人群样本中痛风成人(有或无非痛风对照人群)中慢性肾脏病或肾结石的发生情况。使用随机效应模型进行患病率和风险估计的荟萃分析。
荟萃分析纳入了17项研究(慢性肾脏病7项,肾结石8项,两者均涉及的2项)。痛风患者中慢性肾脏病≥3期和自我报告的终生肾结石的合并患病率估计分别为24%(95%置信区间19%至28%)和14%(95%CI 12%至17%)。痛风与慢性肾脏病(合并调整比值比2.41,95%置信区间1.86至3.11)和自我报告的终生肾结石(1.77,1.43至2.19)均相关。
慢性肾脏病和肾结石在痛风患者中很常见。痛风与慢性肾脏病和肾结石均独立相关。痛风患者应积极筛查慢性肾脏病及其后果。