建立一种携带均匀染色染色体区域并释放α型和β型转化生长因子的人胶质瘤细胞系。
Establishment of a human glioma cell line bearing a homogeneously staining chromosomal region and releasing alpha- and beta-type transforming growth factors.
作者信息
Kanno H, Kuwabara T, Shinonaga M, Chang C C, Tanaka Y, Sugio Y, Morita H, Yasumitsu H, Umeda M, Nagashima Y
机构信息
Department of Neurosurgery, School of Medicine, Yokohama City University, Japan.
出版信息
Acta Neuropathol. 1989;79(1):30-6. doi: 10.1007/BF00308954.
A human glioma cell line (YKG1), which was positively identified for glial fibrillary acidic (GFA) and S-100 proteins, was established from a surgical specimen of a patient with glioblastoma. Chromosome analysis of the cells revealed a homogeneously staining region (HSR) on a marker chromosome. The assay for transforming growth factors (TGFs) in the conditioned medium of the cell line revealed that it contained high levels of alpha- and beta-type TGFs, which might regulate the growth of glioblastoma and influence on the peritumoral tissues.
一种人胶质瘤细胞系（YKG1）从一名胶质母细胞瘤患者的手术标本中建立，该细胞系经胶质纤维酸性蛋白（GFA）和S - 100蛋白阳性鉴定。对这些细胞的染色体分析显示在一条标记染色体上有一个均匀染色区（HSR）。对该细胞系条件培养基中转化生长因子（TGFs）的检测表明，它含有高水平的α型和β型TGFs，这可能调节胶质母细胞瘤的生长并影响肿瘤周围组织。
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