Chiari II型畸形的神经学预后及其与形态学表现和胎儿心率模式的相关性：一项回顾性研究。

Neurological outcomes in Chiari type II malformations and their correlation to morphological findings and fetal heart rate patterns: a retrospective study.

作者信息

Otera Yuka, Morokuma Seiichi, Fukushima Kotaro, Anami Ai, Yumoto Yasuo, Ito Yushi, Ochiai Masayuki, Hashiguchi Kimiaki, Wake Norio, Sago Haruhiko, Kato Kiyoko

机构信息

Center for Maternal-Fetal and Neonatal Medicine, National Center for Child Health and Development, Tokyo, Japan.

Department of Obstetrics and Gynecology, Kyushu University Hospital, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

出版信息

BMC Res Notes. 2015 Feb 27;8:57. doi: 10.1186/s13104-015-1014-2.

DOI:10.1186/s13104-015-1014-2

PMID:25890237

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4349618/

Abstract

BACKGROUND

Correlations among Chiari type II malformation (CMII) morphological findings, the proportion of fetal heart rate patterns corresponding to the quiet phase (QP), and neurological outcomes have yet to be investigated.

FINDINGS

The correlations among the morphological findings (i.e., the degree of ventriculomegaly, myelomeningocele levels, and degree of cerebellar herniation), proportion of time spent in QP, and developmental quotients (DQs) were analyzed in 22 children. The proportion of time spent in QP was compared between children with poor neurological outcomes (n = 9) and those with good outcomes (n = 13). Pearson's correlations and the Mann-Whitney U-test were used to assess for statistical significance; P < 0.05 was considered statistically significant. No significant differences were observed between the DQs and morphological findings, but the DQs and the proportion of time spent in QP were significantly correlated (r = 0.287, P = 0.01). The proportion of time spent in QP was significantly different between children with poor outcomes and those with good outcomes (median, 11% [range, 0-32%] vs. 28% [range, 2-55%]; P = 0.006).

CONCLUSIONS

The proportion of fetal heart rate patterns corresponding to the QP might be a useful predictor of neurological outcomes in 2-year-old children with CMII.

摘要

背景

Chiari II型畸形（CMII）形态学表现、与安静期（QP）相对应的胎儿心率模式比例和神经学预后之间的相关性尚未得到研究。

研究结果

分析了22名儿童的形态学表现（即脑室扩大程度、脊髓脊膜膨出水平和小脑疝程度）、QP期所占时间比例和发育商（DQ）之间的相关性。比较了神经学预后不良儿童（n = 9）和预后良好儿童（n = 13）的QP期所占时间比例。采用Pearson相关性分析和Mann-Whitney U检验评估统计学意义；P < 0.05被认为具有统计学意义。DQ与形态学表现之间未观察到显著差异，但DQ与QP期所占时间比例显著相关（r = 0.287，P = 0.01）。预后不良儿童和预后良好儿童的QP期所占时间比例存在显著差异（中位数，11% [范围，0 - 32%] 对28% [范围，2 - 55%]；P = 0.006）。