Nystagmus responses in a group of normal humans during earth-horizontal axis rotation.

Horizontal eye movement responses to earth-horizontal yaw axis rotation were evaluated in 50 normal human subjects who were uniformly distributed in age (20-69 years) and equally divided by gender for each decade. The subjects were rotated with eyes open in the dark, using clockwise and counterclockwise 60 degree/s velocity trapezoids. The nystagmus slow component velocity (SCV) was analysed using four parameters: Amp, Bias, Mod and Tau. Amp and Tau characterize the canal-ocular reflex to constant velocity steps, while Mod and Bias characterize the "AC" and "DC" components of the otolith-ocular reflex. Results indicated that intersubject variability was larger than that seen in earth-vertical axis data. Tau depended significantly (p less than 0.05) upon subject gender, while Mod increased monotonically with age decade. Linear regression showed a positive correlation between pairs of SCV magnitude parameters (Amp, Bias and Mod), suggesting a common scaling effect. In addition, there was a negative correlation between the value of the decay time constant Tau and each of the three magnitude parameters. Thus, despite large intersubject variability, parameters that describe earth-horizontal yaw axis responses are loosely interrelated and some of them vary significantly with gender and age.