Ryu Heeju, Chung Yeonseok
Laboratory of Immune Regulation, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea.
Laboratory of Immune Regulation, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea.
Cytokine. 2015 Aug;74(2):219-27. doi: 10.1016/j.cyto.2015.03.009. Epub 2015 Apr 15.
Patients with systemic autoimmune diseases exhibit a higher incidence of atherosclerosis. Conversely, hyperlipidemia has been known to accelerate autoimmune diseases in humans as well as in experimental animal. How atherosclerosis impacts autoimmunity remains poorly understood. Importantly, recent studies showed that several pro-atherogenic factors including cholesterol, oxidized low-density lipoprotein and fatty acids regulate the production of IL-17 and IL-17-promoting cytokines from innate and adaptive immune cells. Given that IL-17 is associated with a number of autoimmune diseases in humans, dissecting the mechanisms beyond the mutual regulation of pro-atherogenic factors and IL-17 might provide a novel pathophysiology between atherosclerosis and autoimmune diseases. In this review, we discuss our current understanding related to the role of pro-atherogenic factors in IL-17 production and autoimmune diseases.
患有全身性自身免疫性疾病的患者动脉粥样硬化发病率较高。相反，高脂血症已知会在人类以及实验动物中加速自身免疫性疾病。动脉粥样硬化如何影响自身免疫仍知之甚少。重要的是，最近的研究表明，包括胆固醇、氧化型低密度脂蛋白和脂肪酸在内的几种促动脉粥样硬化因子可调节先天免疫细胞和适应性免疫细胞产生白细胞介素-17（IL-17）以及促进IL-17的细胞因子。鉴于IL-17与人类多种自身免疫性疾病相关，剖析促动脉粥样硬化因子与IL-17相互调节背后的机制可能会揭示动脉粥样硬化与自身免疫性疾病之间新的病理生理学关系。在这篇综述中，我们讨论了目前对促动脉粥样硬化因子在IL-17产生及自身免疫性疾病中作用的理解。
