用（199）Hg核磁共振光谱法直接检测胸腺嘧啶-Hg（II）-胸腺嘧啶碱基对中的汞-氮键。

Direct detection of the mercury-nitrogen bond in the thymine-Hg(II)-thymine base-pair with (199)Hg NMR spectroscopy.

作者信息

Dairaku Takenori, Furuita Kyoko, Sato Hajime, Šebera Jakub, Yamanaka Daichi, Otaki Hiroyuki, Kikkawa Shoko, Kondo Yoshinori, Katahira Ritsuko, Matthias Bickelhaupt F, Fonseca Guerra Célia, Ono Akira, Sychrovský Vladimír, Kojima Chojiro, Tanaka Yoshiyuki

机构信息

Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aza-Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan.

出版信息

Chem Commun (Camb). 2015 May 18;51(40):8488-91. doi: 10.1039/c5cc02423d.

DOI:10.1039/c5cc02423d

PMID:25891069

Abstract

We have observed the 1-bond (199)Hg-(15)N J-coupling ((1)J((199)Hg,(15)N) = 1050 Hz) within the Hg(II)-mediated thymine-thymine base pair (T-Hg(II)-T). This strikingly large (1)J((199)Hg,(15)N) is the first one for canonical sp(2)-nitrogen atoms, which can be a sensitive structure-probe of N-mercurated compounds and a direct evidence for N-mercuration.

摘要

我们已经观测到了汞（II）介导的胸腺嘧啶-胸腺嘧啶碱基对（T-Hg（II）-T）内的一键（199）Hg-（15）N J 耦合（（1）J（（199）Hg，（15）N） = 1050 Hz）。这种显著大的（1）J（（199）Hg，（15）N）对于典型的 sp² 氮原子来说是首次观测到，它可以作为 N-汞化化合物的灵敏结构探针，也是 N-汞化的直接证据。