2006 - 2013年纽约市注射吸毒者中丙型肝炎病毒感染的发病率和患病率

Incidence and prevalence of hepatitis c virus infection among persons who inject drugs in New York City: 2006-2013.

作者信息

Jordan Ashly E, Des Jarlais Don C, Arasteh Kamyar, McKnight Courtney, Nash Denis, Perlman David C

机构信息

The Graduate Center at the City University of New York, 365 Fifth Avenue, New York, NY 10016, USA; Center for Drug Use and HIV Research, New York, NY, USA.

Center for Drug Use and HIV Research, New York, NY, USA; Mount Sinai Beth Israel, Baron Edmond de Rothschild Chemical Dependency Institute, 120 Water St, Floor 24, New York, NY 10038, USA.

出版信息

Drug Alcohol Depend. 2015 Jul 1;152:194-200. doi: 10.1016/j.drugalcdep.2015.03.039. Epub 2015 Apr 13.

DOI:10.1016/j.drugalcdep.2015.03.039

PMID:25891230

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4458155/

Abstract

BACKGROUND

Hepatitis C virus infection is a source of significant preventable morbidity and mortality among persons who inject drugs (PWID). We sought to assess trends in hepatitis C virus (HCV) infection among PWID from 2006 to 2013 in New York City (NYC).

METHODS

Annual cross-sectional surveys of PWID entering a large drug abuse treatment program were performed. Risk behavior questionnaires were administered, and HIV and HCV testing were conducted. Comparisons were made with prior prevalence and incidence estimates in 1990-1991 and 2000-2001 reflecting different periods of combined prevention and treatment efforts.

RESULTS

HCV prevalence among PWID (N: 1535) was 67% (95% CI: 66-70%) during the study period, and was not significantly different from that observed in 2000-2001. The estimated HCV incidence among new injectors (persons injecting for ≤6 years) during 2006-2013 was 19.5/100 PYO (95% CI: 17-23) and did not differ from that observed in 2000-2001 (18/100 PYO, 95% CI: 14-23/100).

CONCLUSIONS

Despite the expansion of combined prevention programming between 2000-2001 and 2006-2013, HCV prevalence remained high. Estimated HCV incidence among new injectors also remained high, and not significantly lower than in 2000-2001, indicating that expanded combined prevention efforts are needed to control the HCV epidemic among PWID in NYC.

摘要

背景

丙型肝炎病毒感染是注射吸毒者（PWID）中可预防的重大发病和死亡原因。我们试图评估2006年至2013年纽约市（NYC）注射吸毒者中丙型肝炎病毒（HCV）感染的趋势。

方法

对进入大型药物滥用治疗项目的注射吸毒者进行年度横断面调查。发放风险行为问卷，并进行艾滋病毒和丙型肝炎病毒检测。与1990 - 1991年和2000 - 2001年之前的患病率和发病率估计值进行比较，这些估计值反映了联合预防和治疗努力的不同时期。

结果

在研究期间，注射吸毒者（N = 1535）中的HCV患病率为67%（95%置信区间：66 - 70%），与2000 - 2001年观察到的患病率无显著差异。2006 - 2013年期间新注射者（注射时间≤6年）的估计HCV发病率为19.5/100人年注射量（95%置信区间：17 - 23），与2000 - 2001年观察到的发病率（18/100人年注射量，95%置信区间：14 - 23/100）无差异。