Chapman Helena J, Phillips Sarah A, Hosford Jennifer L, Séraphin Marie Nancy, Lauzardo Michael
Southeastern National Tuberculosis Center, Division of Infectious Diseases and Global Medicine, University of Florida College of Medicine, 2055 Mowry Road, Gainesville, FL 32611, United States.
Southeastern National Tuberculosis Center, Division of Infectious Diseases and Global Medicine, University of Florida College of Medicine, 2055 Mowry Road, Gainesville, FL 32611, United States; Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, 2004 Mowry Road, Gainesville, FL 32610, United States.
Infect Genet Evol. 2015 Jul;33:1-5. doi: 10.1016/j.meegid.2015.04.012. Epub 2015 Apr 16.
We conducted a cross-sectional study to describe clinical characteristics of patients with pulmonary tuberculosis with and without evidence of pulmonary cavitation on chest radiography and assess whether cavitation is associated with infection with Mycobacterium tuberculosis Beijing strain. Cases were selected from the Tuberculosis Registry (January 1, 2008-November 1, 2011) of the Florida Department of Health (FDOH). Molecular characterization was performed by spoligotyping and MIRU-VNTR. We analyzed 975 cases, where 144 (14.8%) were infected with the Beijing strain. Cavitation was not associated with disease caused by the Beijing strain. Alcohol use (OR = 1.7; 95%CI: 1.249-2.313) was associated with increased risk of cavitation in the unadjusted analyses. Multivariable analyses showed that older age (⩾ 65 years) (OR = 0.5; 95%CI: 0.233-0.871), Hispanic ethnicity (OR = 0.6; 95%CI: 0.312-0.962), and co-infection with HIV (OR = 0.1; 95%CI: 0.068-0.295) demonstrated protective effects to cavitation. Understanding the factors associated with cavitation among pulmonary cases is essential toward improved tuberculosis management and control.
我们开展了一项横断面研究，以描述胸部X光片上有和无肺空洞证据的肺结核患者的临床特征，并评估空洞是否与结核分枝杆菌北京株感染有关。病例选自佛罗里达州卫生部（FDOH）的结核病登记处（2008年1月1日至2011年11月1日）。通过间隔寡核苷酸分型（spoligotyping）和多位点可变数目串联重复序列分析（MIRU-VNTR）进行分子特征分析。我们分析了975例病例，其中144例（14.8%）感染了北京株。空洞与北京株引起的疾病无关。在未经调整的分析中，饮酒（比值比[OR]=1.7；95%置信区间[CI]：1.249 - 2.313）与空洞形成风险增加相关。多变量分析显示，年龄较大（≥65岁）（OR = 0.5；95%CI：0.233 - 0.871）、西班牙裔种族（OR = 0.6；95%CI：0.312 - 0.962）和合并感染艾滋病毒（OR = 0.1；95%CI：0.068 - 0.295）对空洞形成具有保护作用。了解肺部病例中空洞形成的相关因素对于改善结核病的管理和控制至关重要。
