Żelaźniewicz Agnieszka, Nowak Judyta, Pawłowski Bogusław
Department of Human Biology, University of Wroclaw, Wroclaw, Poland.
Am J Hum Biol. 2015 Nov-Dec;27(6):816-21. doi: 10.1002/ajhb.22730. Epub 2015 Apr 18.
High level of oxidative stress (OS) during the first weeks of pregnancy is related to many serious pregnancy complications. Previous studies showed that body fluctuating asymmetry (FA) is related to OS level in men, suggesting that FA is a marker of oxidative balance in an individual. The aim of this study was to analyze if body FA was related to the level of biomarkers of OS in the first trimester of pregnancy.
The sample included 34 women in the first trimester of pregnancy, not smoking, and not exposed to toxins in their work environment. The composite FA and levels of two biomarkers of OS, 8-iso-ProstaglandinF2α (an indicator of oxidative damage to lipids) and 8-OH-dG (an indicator of oxidative damage to DNA) were measured. Factors that may affect the level of OS (vitamin supplementation, age, smoking, alcohol drinking, physical activity, and health condition) were controlled.
The levels of OS markers in the first trimester of pregnancy correlated positively with women's FA (r = 0.52, P = 0.002 for 8-OH-dG; r = 0.50; P = 0.003 for 8-iso-PGF2α level) and positively with body height (r = 0.37, P = 0.03 for 8-OH-dG level).
The level of OS is likely to be a substantial and important fitness trait, and FA may convey information on the level of OS in women. The result confirms that FA is an indicator of biological condition, as suggested by an evolutionary approach to morphological human traits perceived as attractive.
孕期头几周的高水平氧化应激（OS）与许多严重的妊娠并发症相关。先前的研究表明，身体波动不对称性（FA）与男性的OS水平相关，这表明FA是个体氧化平衡的一个指标。本研究的目的是分析孕期头三个月身体FA是否与OS生物标志物水平相关。
样本包括34名孕期头三个月的女性，她们不吸烟，且工作环境中未接触毒素。测量了综合FA以及两种OS生物标志物的水平，即8-异前列腺素F2α（脂质氧化损伤的指标）和8-羟基脱氧鸟苷（DNA氧化损伤的指标）。对可能影响OS水平的因素（维生素补充、年龄、吸烟、饮酒、体育活动和健康状况）进行了控制。
孕期头三个月的OS标志物水平与女性的FA呈正相关（8-羟基脱氧鸟苷：r = 0.52，P = 0.002；8-异前列腺素F2α水平：r = 0.50，P = 0.003），与身高也呈正相关（8-羟基脱氧鸟苷水平：r = 0.37，P = 0.03）。
OS水平可能是一个重要的健康特征，而FA可能传达女性OS水平的信息。结果证实，FA是一种生物学状况的指标，这与从进化角度看待被认为有吸引力的人类形态特征的观点一致。
