• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Quercus infectoria Gall Extract Enhanced the Proliferation and Activity of Human Fetal Osteoblast Cell Line (hFOB 1.19).没食子酸栎提取物增强了人胎儿成骨细胞系（hFOB 1.19）的增殖和活性。
Malays J Med Sci. 2015 Jan-Feb;22(1):12-22.
2
Proliferation study and microscopy evaluation on the effects of tannic acid in human fetal osteoblast cell line (hFOB 1.19).单宁酸对人胎儿成骨细胞系（hFOB 1.19）影响的增殖研究及显微镜评估
Microsc Res Tech. 2019 Nov;82(11):1928-1940. doi: 10.1002/jemt.23361. Epub 2019 Aug 19.
3
The Role of Semipurified Fractions Isolated from on Bone Metabolism by Using hFOB 1.19 Human Fetal Osteoblast Cell Model.使用hFOB 1.19人胎儿成骨细胞模型研究从[具体来源未给出]分离的半纯化组分对骨代谢的作用。
Evid Based Complement Alternat Med. 2018 May 13;2018:5319528. doi: 10.1155/2018/5319528. eCollection 2018.
4
The Investigation of Gall Aqueous Extract Effect on the Cell Proliferation, Apoptosis and Expression of , , and Genes in Cell Line of Lung, Gastric and Esophageal Cancers.胆汁水提取物对肺癌、胃癌和食管癌细胞系细胞增殖、凋亡及 、 、 和 基因表达的影响研究
Rep Biochem Mol Biol. 2024 Jan;12(4):596-608. doi: 10.61186/rbmb.12.4.596.
5
Effects of gonadal and adrenal androgens in a novel androgen-responsive human osteoblastic cell line.性腺和肾上腺雄激素在一种新型雄激素反应性人成骨细胞系中的作用。
J Cell Biochem. 1998 Oct 1;71(1):96-108.
6
Cryopreservation of osteoblast-like cells: viability and differentiation with replacement of fetal bovine serum in vitro.成骨样细胞的冷冻保存：体外替代胎牛血清时的活力与分化
Cells Tissues Organs. 2006;183(1):32-40. doi: 10.1159/000094904.
7
In vitro response of hFOB cells to pamidronate modified sodium silicate coated cellulose scaffolds.人成骨细胞系hFOB对帕米膦酸修饰的硅酸钠包被纤维素支架的体外反应
Colloids Surf B Biointerfaces. 2008 Jul 15;64(2):275-83. doi: 10.1016/j.colsurfb.2008.02.002. Epub 2008 Feb 14.
8
Development and characterization of a conditionally immortalized human fetal osteoblastic cell line.一种条件永生化人胎儿成骨细胞系的建立与鉴定
J Bone Miner Res. 1995 Feb;10(2):178-86. doi: 10.1002/jbmr.5650100203.
9
Phytochemicals and Cytotoxicity of Ethyl Acetate Extracts on Human Cancer Cells.乙酸乙酯提取物对人癌细胞的植物化学物质及细胞毒性
Trop Life Sci Res. 2020 Apr;31(1):69-84. doi: 10.21315/tlsr2020.31.1.5. Epub 2020 Apr 7.
10
Bisphosphonates directly regulate cell proliferation, differentiation, and gene expression in human osteoblasts.双膦酸盐直接调节人成骨细胞的细胞增殖、分化和基因表达。
Cancer Res. 2000 Nov 1;60(21):6001-7.

引用本文的文献

1
Gall Ethanolic Extract Accelerates Wound Healing through Attenuating Inflammation and Oxidative Injuries in Skin Fibroblasts.胆汁乙醇提取物通过减轻皮肤成纤维细胞的炎症和氧化损伤来加速伤口愈合。
Antioxidants (Basel). 2024 Sep 9;13(9):1094. doi: 10.3390/antiox13091094.
2
Removal of Typhimurium Biofilm from Food Contact Surfaces Using Gall Extract in Combination with a Surfactant.利用鹅去氧胆酸提取物与表面活性剂联合去除食品接触面的鼠伤寒沙门氏菌生物膜。
J Microbiol Biotechnol. 2021 Mar 28;31(3):439-446. doi: 10.4014/jmb.2101.01014.
3
Medicinal Uses, Phytochemistry, and Pharmacological Activities of Species.物种的药用用途、植物化学和药理活性。
Evid Based Complement Alternat Med. 2020 Jul 31;2020:1920683. doi: 10.1155/2020/1920683. eCollection 2020.
4
The Role of Semipurified Fractions Isolated from on Bone Metabolism by Using hFOB 1.19 Human Fetal Osteoblast Cell Model.使用hFOB 1.19人胎儿成骨细胞模型研究从[具体来源未给出]分离的半纯化组分对骨代谢的作用。
Evid Based Complement Alternat Med. 2018 May 13;2018:5319528. doi: 10.1155/2018/5319528. eCollection 2018.
5
Gallnuts: A Potential Treasure in Anticancer Drug Discovery.五倍子：抗癌药物研发中的潜在宝库。
Evid Based Complement Alternat Med. 2018 Mar 29;2018:4930371. doi: 10.1155/2018/4930371. eCollection 2018.
6
Dexmedetomidine attenuates HO-induced cell death in human osteoblasts.右美托咪定减轻人成骨细胞中HO诱导的细胞死亡。
J Dent Anesth Pain Med. 2016 Dec;16(4):295-302. doi: 10.17245/jdapm.2016.16.4.295. Epub 2016 Dec 31.

本文引用的文献

1
Pharmacognostic studies of insect gall of Quercus infectoria Olivier (Fagaceae).没食子（壳斗科，没食子树）虫瘿的生药学研究。
Asian Pac J Trop Biomed. 2014 Jan;4(1):35-9. doi: 10.1016/S2221-1691(14)60205-7.
2
Efficacy of pamidronate in children with low bone mineral density during and after chemotherapy for acute lymphoblastic leukemia and non-Hodgkin lymphoma.帕米膦酸对急性淋巴细胞白血病和非霍奇金淋巴瘤化疗期间及化疗后骨密度低的儿童的疗效。
Blood Res. 2013 Jun;48(2):99-106. doi: 10.5045/br.2013.48.2.99. Epub 2013 Jun 25.
3
Comparison between 8-prenylnarigenin and narigenin concerning their activities on promotion of rat bone marrow stromal cells' osteogenic differentiation in vitro.8-异戊烯基柚皮素和柚皮素促进体外大鼠骨髓基质细胞成骨分化活性的比较。
Cell Prolif. 2012 Dec;45(6):508-15. doi: 10.1111/j.1365-2184.2012.00844.x.
4
Sesamin stimulates osteoblast differentiation through p38 and ERK1/2 MAPK signaling pathways.芝麻素通过 p38 和 ERK1/2 MAPK 信号通路刺激成骨细胞分化。
BMC Complement Altern Med. 2012 May 30;12:71. doi: 10.1186/1472-6882-12-71.
5
Effects of Tinospora cordifolia (Menispermaceae) on the proliferation, osteogenic differentiation and mineralization of osteoblast model systems in vitro.三叶鬼针草（防己科）对体外成骨细胞模型系统增殖、成骨分化和矿化的影响。
J Ethnopharmacol. 2012 May 7;141(1):474-80. doi: 10.1016/j.jep.2012.03.015. Epub 2012 Mar 20.
6
Effects of pamidronate on human alveolar osteoblasts in vitro.帕米膦酸盐对人牙槽成骨细胞的体外作用。
J Oral Maxillofac Surg. 2012 May;70(5):1081-92. doi: 10.1016/j.joms.2011.05.002.
7
Adhesion pattern and growth of primary human osteoblastic cells on five commercially available titanium surfaces.五种市售钛表面上原代人成骨细胞的黏附模式和生长情况。
Clin Oral Implants Res. 2010 Jul;21(7):756-65. doi: 10.1111/j.1600-0501.2009.01906.x.
8
Long Term Cyclic Pamidronate Reduces Bone Growth by Inhibiting Osteoclast Mediated Cartilage-to-Bone Turnover in the Mouse.长期循环使用帕米膦酸盐通过抑制破骨细胞介导的小鼠软骨到骨的转换来减少骨生长。
Open Orthop J. 2008 Jul 14;2:121-5. doi: 10.2174/1874325000802010121.
9
When nutrition interacts with osteoblast function: molecular mechanisms of polyphenols.当营养与成骨细胞功能相互作用时：多酚的分子机制
Nutr Res Rev. 2009 Jun;22(1):68-81. doi: 10.1017/S095442240926402X. Epub 2009 Feb 26.
10
In vitro response of hFOB cells to pamidronate modified sodium silicate coated cellulose scaffolds.人成骨细胞系hFOB对帕米膦酸修饰的硅酸钠包被纤维素支架的体外反应
Colloids Surf B Biointerfaces. 2008 Jul 15;64(2):275-83. doi: 10.1016/j.colsurfb.2008.02.002. Epub 2008 Feb 14.

没食子酸栎提取物增强了人胎儿成骨细胞系（hFOB 1.19）的增殖和活性。

Quercus infectoria Gall Extract Enhanced the Proliferation and Activity of Human Fetal Osteoblast Cell Line (hFOB 1.19).

作者信息

Hapidin Hermizi, Rozelan Dalila, Abdullah Hasmah, Wan Hanaffi Wan Nurhidayah, Soelaiman Ima Nirwana

机构信息

Biomedicine Program, School of Health Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia.

Environmental and Occupational Health Program, School of Health Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia.

出版信息

Malays J Med Sci. 2015 Jan-Feb;22(1):12-22.

PMID:25892946
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4390770/
Abstract

BACKGROUND

The present study investigated the effects of Quercus infectoria (QI) gall extract on the proliferation, alkaline phosphatase (ALP), osteocalcin, and the morphology of a human fetal osteoblast cell line (hFOB 1.19).

METHODS

The cells were cultured in Dulbecco's modified eagle medium F12 supplemented with a 10% fetal bovine serum, a 1% penicillin/streptomycin and were treated with QI at various concentrations (0.1 to 99.0 μg/mL) for 72 hours. The levels of ALP and osteocalcin were measured at day 1, 3, 7, 10, and 14 and were compared among the negative control, pamidronate and QI groups.

RESULTS

The median effective concentration (EC50) of hFOB 1.19 treated with QI was 10.30 μg/mL. This concentration was more effective compared to the control drug, pamidronate (EC50 at 16.09 μg/mL). The ALP and osteocalcin levels of hFOB 1.19 treated with QI from day 7 and onwards were significantly increased in a time and concentration-dependent manner. Interestingly, from day 7 until day 14, the ALP and osteocalcin levels were highest in the cells treated with QI compared to the other two groups. The morphology of cells treated with QI was uniformly elongated, higher in number and over-confluent.

CONCLUSION

After treatment with QI, cell proliferation enhanced and ALP and osteocalcin levels increased.

摘要

背景

本研究调查了没食子（QI）虫瘿提取物对人胎儿成骨细胞系（hFOB 1.19）增殖、碱性磷酸酶（ALP）、骨钙素及细胞形态的影响。

方法

细胞在补充有10%胎牛血清、1%青霉素/链霉素的杜氏改良 Eagle 培养基F12中培养，并用不同浓度（0.1至99.0μg/mL）的QI处理72小时。在第1、3、7、10和14天测量ALP和骨钙素水平，并在阴性对照、帕米膦酸盐和QI组之间进行比较。

结果

用QI处理的hFOB 1.19的半数有效浓度（EC50）为10.30μg/mL。该浓度比对照药物帕米膦酸盐（EC50为16.09μg/mL）更有效。从第7天及以后，用QI处理的hFOB 1.19的ALP和骨钙素水平以时间和浓度依赖性方式显著增加。有趣的是，从第7天到第14天，与其他两组相比，用QI处理的细胞中ALP和骨钙素水平最高。用QI处理的细胞形态均匀拉长，数量更多且过度汇合。

结论

用QI处理后，细胞增殖增强，ALP和骨钙素水平升高。