Malone K E, Koepsell T D, Daling J R, Weiss N S, Morris P D, Taylor J W, Swanson G M, Lyon J L
Department of Epidemiology, University of Washington, Seattle.
Am J Epidemiol. 1989 Dec;130(6):1152-8. doi: 10.1093/oxfordjournals.aje.a115442.
As part of a population-based case-control study carried out in four areas of the United States, 427 cases of chronic lymphocytic leukemia diagnosed between July 1, 1977, and December 31, 1981, and 1,683 controls were interviewed regarding their history of chemical exposure. Respondents were asked if they had ever been "highly exposed" at home, at work, or elsewhere to one or more of a list of chemicals or to any other such substances not on the list. These chemicals were categorized into 20 exposure groups based on chemical composition. Odds ratios were calculated adjusting for age, sex, race, education level, and geographic location by means of unconditional logistic regression. Increased risks were associated with reported past exposure to acid-containing chemicals, "other caustic substances," aliphatic hydrocarbons, and chlorinated hydrocarbons. Because of the large number of exposures investigated in this study, and because of the relatively imprecise means the authors had to assess exposure, further research is needed to verify these findings.
作为一项在美国四个地区开展的基于人群的病例对照研究的一部分，对1977年7月1日至1981年12月31日期间确诊的427例慢性淋巴细胞白血病病例以及1683名对照者进行了化学物暴露史访谈。受访者被问及他们是否曾在家中、工作场所或其他地方“高度暴露”于一份化学物清单中的一种或多种化学物，或清单之外的任何其他此类物质。这些化学物根据化学成分被分为20个暴露组。通过无条件逻辑回归对年龄、性别、种族、教育水平和地理位置进行校正后计算比值比。报告过去接触含酸化学物、“其他腐蚀性物质”、脂肪烃和氯代烃与风险增加相关。由于本研究调查的暴露因素众多，且作者评估暴露的方法相对不精确，因此需要进一步研究来验证这些发现。
