吸烟与白血病：路德兄弟队列研究的结果

Cigarette smoking and leukemia: results from the Lutheran Brotherhood Cohort Study.

作者信息

Linet M S, McLaughlin J K, Hsing A W, Wacholder S, Co-Chien H T, Schuman L M, Bjelke E, Blot W J

机构信息

Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, MD 20892.

出版信息

Cancer Causes Control. 1991 Nov;2(6):413-7. doi: 10.1007/BF00054302.

DOI:10.1007/BF00054302

PMID:1764566

Abstract

In a 20-year follow-up (1966-86) of 17,633 White males who described tobacco use in a mailed questionnaire sent in 1966, there were 74 deaths from leukemia (including 30 myeloid, 30 lymphatic, and 14 other and unspecified leukemia). Among men who ever smoked cigarettes, increased risks were observed for lymphatic (relative risk [RR] = 2.7), and other and unspecified leukemia (RR = 1.5); risks rose with increasing number of cigarettes smoked, although the dose-response relationship was statistically significant only for total leukemia. Mortality from myeloid leukemia was not elevated, except among those smoking over a pack of cigarettes per day. Results from this cohort support a relationship between cigarette smoking and leukemia. Further studies are needed to elucidate subtype associations with cigarette smoking.

摘要

在一项对1966年通过邮寄问卷描述过烟草使用情况的17633名白人男性进行的为期20年（1966 - 1986年）的随访中，有74人死于白血病（包括30例髓细胞性白血病、30例淋巴细胞性白血病以及14例其他类型和未明确类型的白血病）。在曾经吸烟的男性中，观察到淋巴细胞性白血病（相对风险[RR]=2.7）以及其他类型和未明确类型的白血病（RR = 1.5）的风险增加；风险随着吸烟量的增加而上升，尽管剂量反应关系仅对总白血病具有统计学意义。髓细胞性白血病的死亡率没有升高，除非是那些每天吸烟超过一包的人。该队列研究结果支持吸烟与白血病之间存在关联。需要进一步研究以阐明吸烟与各亚型白血病之间的关联。