采用动脉自旋标记（ASL）和血氧水平依赖性功能磁共振成像（BOLD MRI）评估3T条件下对比剂诱导的急性肾损伤（CIAKI）大鼠的肾功能损害。

To evaluate the damage of renal function in CIAKI rats at 3T: using ASL and BOLD MRI.

作者信息

Chen Wen-Bo, Liang Long, Zhang Bin, Liu Chun-Ling, Liu Hong-Jun, Luo Hai-Ying, Zeng Qiong-Xin, Liang Chang-Hong, Liu Guan-Shu, Zhang Shui-Xing

机构信息

Department of Radiology, Guangdong Academy of Medical Sciences/Guangdong General Hospital, No. 106 Zhongshan Er Road, Guangzhou, Guangdong Province 510080, China ; Department of Radiology, HuiZhou Municipal Central Hospital, No. 41 E Ling Bei Road, Huizhou, Guangdong Province 516008, China.

Department of Radiology, Guangdong Academy of Medical Sciences/Guangdong General Hospital, No. 106 Zhongshan Er Road, Guangzhou, Guangdong Province 510080, China ; Southern Medical University, No. 1838 Dadao Bei Road, Guangzhou, Guangdong Province 510515, China.

出版信息

Biomed Res Int. 2015;2015:593060. doi: 10.1155/2015/593060. Epub 2015 Mar 29.

PURPOSE

To investigate noninvasive arterial spin-labeling (ASL) and blood oxygen level-dependent imaging (BOLD) sequences for measuring renal hemodynamics and oxygenation in contrast induced acute kidney injury (CIAKI) rat.

MATERIALS AND METHODS

Thirteen SD rats were randomly grouped into CIAKI group and control group. Both ASL and BOLD sequences were performed at 24 h preinjection and at intervals of 0.5, 12, 24, 48, 72, and 96 h postinjection to assess renal blood flow (RBF) and relative spin-spin relaxation rate (R2(*)), respectively.

RESULTS

For the CIAKI group, the value of RBF in the cortex (CO) and outer medulla (OM) of the kidney was significantly decreased (P < 0.05) at 12-48 h and regressed to baseline level (P = NS) at 72-96 h. In OM, the value of R2(*) was increased at 0.5-48 h (P < 0.05) and not statistically significant (P = NS) at 72 and 96 h.

CONCLUSIONS

RBF in OM and CO and oxygen level in OM were decreased postinjection of CM. ASL combining BOLD can further identify the primary cause of the decrease of renal oxygenation in CIAKI. This approach provides means for noninvasive monitoring renal function during the first 4 days of CIAKI in clinical routine work.