Li Jinkui, Yan Ruifeng, Lei Junqiang, Jiang Changqin
The First Clinical Medical School of Lanzhou University, Lanzhou, Gansu, China.
The First Hospital of Lanzhou Univesity, Lanzhou, Gansu, China.
Abdom Imaging. 2015 Oct;40(7):2660-6. doi: 10.1007/s00261-015-0418-8.
The study aims to perform a meta-analysis to compare the diagnostic value of FDG PET with PET/CT in detecting peritoneal carcinomatosis (PC) to identify the potentially most useful diagnostic modality.
A computer-aided search was performed in the Cochrane Library, PubMed, EMBASE, Web of Science, the China Biological Medicine Database, VIP, China National Knowledge Infrastructure database, and Wanfang databases for articles concerning diagnosis of peritoneal metastases with PET or PET/CT. QUADAS was used to evaluate the included articles' quality.
On a per-patient basis, the pooled sensitivity of PET/CT (84%) was significantly higher than that of PET (60%), and the pooled specificity of PET (98%) was markedly higher than that for PET/CT (94%). On a per-lesion basis, the pooled sensitivity and specificity of PET/CT were 87 and 95%, respectively. Only 1 PET study on a per-lesion basis, its sensitivity is 65.8 and specificity is 94.1%.
PET and PET/CT are powerful imaging techniques for detection and characterization of PC. PET/CT can be used as a screening tool and it may be acceptable to use PET as a diagnosis tool.
本研究旨在进行一项荟萃分析，比较氟代脱氧葡萄糖正电子发射断层扫描（FDG PET）与PET/CT在检测腹膜癌转移（PC）中的诊断价值，以确定可能最有用的诊断方式。
在考克兰图书馆、PubMed、EMBASE、科学网、中国生物医学数据库、维普资讯、中国知网数据库和万方数据库中进行计算机辅助检索，查找有关PET或PET/CT诊断腹膜转移的文章。使用QUADAS评估纳入文章的质量。
以每位患者为基础，PET/CT的合并敏感度（84%）显著高于PET（60%），PET的合并特异度（98%）明显高于PET/CT（94%）。以每个病灶为基础，PET/CT的合并敏感度和特异度分别为87%和95%。仅1项基于每个病灶的PET研究，其敏感度为65.8%，特异度为94.1%。
PET和PET/CT是检测和鉴别PC的强大成像技术。PET/CT可作为一种筛查工具，将PET用作诊断工具可能也是可以接受的。
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