Zhang Caiguo, Liu Yan
Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO, 80045, USA,
J Nat Med. 2015 Jul;69(3):255-66. doi: 10.1007/s11418-015-0911-y. Epub 2015 Apr 19.
Cancer remains a major cause of death in the world to date. A variety of anticancer drugs have been used in clinical chemotherapy, acting on the particular oncogenic abnormalities that are responsible for malignant transformation and progression. Interestingly, some of these anticancer drugs are developed from natural sources such as plants, marine organisms, and microorganisms. Over the past decades, a family of naturally occuring molecules, namely sesterterpenoids, has been isolated from different organisms and they exhibit significant potential in the inhibition of tumor cells in vitro, while the molecular targets of these compounds and their functional mechanisms are still obscure. In this review, we summarize and discuss the functions of these sesterterpenoids in the inhibition of cancer cells. Moreover, we also highlight and discuss chemical structure-activity relationships of some compounds, demonstrating their pervasiveness and importance in cancer therapy.
迄今为止，癌症仍是全球主要的死亡原因。多种抗癌药物已用于临床化疗，作用于导致恶性转化和进展的特定致癌异常。有趣的是，其中一些抗癌药物是从植物、海洋生物和微生物等天然来源开发的。在过去几十年中，一类天然存在的分子，即倍半萜内酯，已从不同生物体中分离出来，它们在体外对肿瘤细胞的抑制具有显著潜力，而这些化合物的分子靶点及其作用机制仍不清楚。在本综述中，我们总结并讨论了这些倍半萜内酯在抑制癌细胞方面的作用。此外，我们还重点介绍并讨论了一些化合物的化学结构 - 活性关系，展示了它们在癌症治疗中的普遍性和重要性。
