Subramaniam T, Lennon P, O'Neill J P
Department of Otolaryngology, Head and Neck Surgery, Beaumont Hospital, Dublin, Ireland,
Ir J Med Sci. 2015 Sep;184(3):583-90. doi: 10.1007/s11845-015-1298-1. Epub 2015 Apr 17.
Adenoid cystic carcinoma is a malignant tumour of major and minor salivary glands. Distant metastasis and poor survival are persistent in the literature, with recent publications aimed at understanding molecular pathogenesis and development of pharmaceutical therapeutic options.
Provide an update of recent studies in the management of adenoid cystic carcinoma of the head and neck.
Literature search using Medline, Scopus, Google Scholar, the Cochrane Database of Systematic Reviews and the Cochrane central register of controlled trials for articles on adenoid cystic carcinoma from January 2005 to January 2015.
Adenoid cystic carcinoma is characterized by a slow growing mass, with distant metastasis independent of local or regional control. Primary tumour resection remains the preferred option with radiotherapy having an adjuvant role. Recent advances have been made with novel targeted therapies however, limited to clinical trials and advanced disease.
腺样囊性癌是大、小唾液腺的一种恶性肿瘤。远处转移和较差的生存率在文献中一直存在，近期的出版物旨在了解分子发病机制和药物治疗选择的发展。
提供头颈部腺样囊性癌治疗的近期研究进展。
使用Medline、Scopus、谷歌学术、Cochrane系统评价数据库和Cochrane对照试验中心注册库检索2005年1月至2015年1月关于腺样囊性癌的文章。
腺样囊性癌的特征是肿块生长缓慢，远处转移独立于局部或区域控制。原发性肿瘤切除仍然是首选方案，放疗起辅助作用。然而，新型靶向治疗虽有进展，但仅限于临床试验和晚期疾病。
