Instituto Nacional de Salud Pública, Cuernavaca, Morelos, Mexico.
Centro de Investigación en Nutrición y Salud, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, Mexico.
Clin Nutr. 2015 Oct;34(5):799-804. doi: 10.1016/j.clnu.2014.10.002. Epub 2014 Oct 13.
BACKGROUND & AIMS: Dyslipidemia is a risk factor for cardiovascular disease that has become an increasing public health problem. Dyslipidemia is especially relevant in vulnerable populations such as postmenopausal women. Low serum levels of 25-hydroxyvitamin D have been associated with an unfavourable lipid profile. Due to contradictory findings from intervention trials, we investigated the effect of vitamin D supplementation on serum lipids in postmenopausal women with type 2 diabetes.
A total of 104 postmenopausal women with type 2 diabetes were randomly assigned in a double-blind manner to 1 of 2 groups taking a daily tablet for 6 months: a group consuming 4000 IU tablets of a vitamin D supplement (vitamin D group n = 52) or a group consuming placebo tablets (placebo group n = 52).
The study was completed by 99 participants. However, as the analysis was based on an intention-to-treat approach, all 104 women were included in the final analysis. In the vitamin D group mean serum levels of 25(OH)D3 improved significantly at the end of the follow-up period (+25.5 nmol/L; P = <0.001). Our findings revealed no significant changes in low density lipoproteins, high density lipoproteins and total cholesterol concentrations, but did identify a greater decrease in serum triglycerides in the vitamin D group. The average effect of supplementation on the treated group was -34.24 mg/dL (P = 0.021), while the average treatment effect was -31.8 mg/dL (P = 0.023).
Our results suggest that supplementation with vitamin D (4000 IU/d) may have a beneficial effect on serum triglyceride levels without otherwise affecting levels of other lipids.
clinicaltrial.gov; identifier NCT01019642.
血脂异常是心血管疾病的一个危险因素，已成为一个日益严重的公共卫生问题。血脂异常在绝经后妇女等脆弱人群中尤为相关。血清 25-羟维生素 D 水平低与不良的血脂谱有关。由于干预试验的结果存在矛盾，我们研究了维生素 D 补充剂对 2 型糖尿病绝经后妇女血清脂质的影响。
共 104 名绝经后 2 型糖尿病妇女以双盲方式随机分为两组，每天服用 1 片，持续 6 个月：一组服用 4000IU 维生素 D 补充剂片（维生素 D 组，n = 52），另一组服用安慰剂片（安慰剂组，n = 52）。
99 名参与者完成了研究。然而，由于分析基于意向治疗方法，所有 104 名妇女都包括在最终分析中。在维生素 D 组，治疗结束时 25（OH）D3 血清水平显著改善（+25.5 nmol/L；P <0.001）。我们的研究结果显示，低密度脂蛋白、高密度脂蛋白和总胆固醇浓度没有显著变化，但发现维生素 D 组血清甘油三酯降低幅度更大。补充剂对治疗组的平均作用为-34.24mg/dL（P = 0.021），而平均治疗作用为-31.8mg/dL（P = 0.023）。
我们的结果表明，补充维生素 D（4000IU/d）可能对血清甘油三酯水平有有益影响，而对其他脂质水平没有影响。
clinicaltrial.gov；标识符 NCT01019642。
