David Muniswamy, Sangeetha Jeyabalan, Harish Etigemane R
J Environ Biol. 2015 Mar;36(2):405-8.
Sodium cyanide is a common environmental pollutant which is mainly used in many industries such as mining, electroplating, steel manufacturing, pharmaceutical production and other specialized applications including dyes and agricultural products. It enters aquatic environment through effluents from these industries. Static renewal bioassay test has been conducted to determine LC, of sodium cyanide on indigenous freshwater carp, Labeo rohita. The behavioural pattern and oxygen consumption were observed in fish at both lethal and sub lethal concentrations. Labeo rohita in toxic media exhibited irregular and erratic swimming movements, hyper excitability, loss of equilibrium and shrinking to the bottom, which may be due to inhibition of cytochrome C oxidase activity and decreased blood pH. The combination of cytotoxic hypoxia with lactate acidosis depresses the central nervous system resulting in respiratory arrest and death. Decrease in oxygen consumption was observed at both lethal and sub lethal concentrations of sodium cyanide. Mortality was insignificant at sub lethal concentration test when fishes were found under stress. Consequence of impaired oxidative metabolism and elevated physiological response by fish against sodium cyanide stress showed alteration in respiratory rate.
氰化钠是一种常见的环境污染物，主要用于采矿、电镀、钢铁制造、药品生产等众多行业以及包括染料和农产品在内的其他特殊应用领域。它通过这些行业的废水进入水生环境。已进行静态更新生物测定试验以确定氰化钠对本地淡水鲤鱼（印度野鲮）的半数致死浓度（LC）。在致死浓度和亚致死浓度下观察了鱼类的行为模式和耗氧量。处于有毒介质中的印度野鲮表现出不规则且不稳定的游动、过度兴奋、失去平衡并蜷缩至水底，这可能是由于细胞色素C氧化酶活性受到抑制以及血液pH值降低所致。细胞毒性缺氧与乳酸性酸中毒相结合会抑制中枢神经系统，导致呼吸骤停和死亡。在氰化钠的致死浓度和亚致死浓度下均观察到耗氧量下降。在亚致死浓度试验中，当鱼类处于应激状态时，死亡率并不显著。鱼类氧化代谢受损以及对氰化钠应激的生理反应增强的结果显示呼吸频率发生了改变。
