Gao Qingjun, Zhao Daiwei
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2014 Dec;28(24):1938-40.
To investigate the clinical application of carbon nanoparticles staining in cervical lymph node dissection on clinical neck lymph nodes the negative (cN0 period) thyroid papillary thyroid carcinoma (PTC).
This retrospective analysis comprised 100 papillary thyroid cancer patients who met inclusion criteria,and they were randomly divided into the nano-carbon group (50 cases) and control group (50 cases). They underwent lobectomy, subtotal thyroidectomy or total thyroidectomies and were given elective central compartment neck dissection (CCND). The number of detected lymph nodes in each group was summed, and pathological examination was conducted. The number of lymph nodes (dyedor not dyed) and the location of metastatic nodes were recorded separately.
In the nano-carbon group the average number of eliminated lymph nodes is significantly more than that of the control group(P<0.05). The metastasis lymph nodes in the nano-carbon group was higher than that in the control group(P<0.01). Among 100 cases, 2% had temporary vocal cord palsy, and 8% had temporary hypoparat hyroidism. No case of permanent vocal cord palsy or permanent hypocalcemia was observed.
The dyed lymph nodes can be easily identified and can be used as a guide for lymphnodes dissection in papillary thyroid carcinoma operation.
探讨纳米碳混悬液染色法在临床颈部淋巴结阴性（cN0期）甲状腺乳头状癌（PTC）颈淋巴结清扫术中的临床应用。
回顾性分析100例符合纳入标准的甲状腺乳头状癌患者，将其随机分为纳米碳组（50例）和对照组（50例）。两组患者均行甲状腺叶切除术、甲状腺次全切除术或甲状腺全切除术，并进行选择性中央区颈淋巴结清扫术（CCND）。汇总每组中检测到的淋巴结数量，并进行病理检查。分别记录染色及未染色淋巴结的数量以及转移淋巴结的位置。
纳米碳组清扫淋巴结的平均数明显多于对照组（P<0.05）。纳米碳组转移淋巴结数高于对照组（P<0.01）。100例患者中，2%出现暂时性声带麻痹，8%出现暂时性甲状旁腺功能减退。未观察到永久性声带麻痹或永久性低钙血症病例。
纳米碳混悬液染色法可使术中淋巴结易于识别，为甲状腺乳头状癌手术的淋巴结清扫提供指引。
