Aly M R E, Ibrahim M M, Okael A M, Gherbawy Y A M H
Bioorg Khim. 2014 Mar-Apr;40(2):234-47.
This paper describes the synthesis of a series of quinolines graphted with hydrazones, pyrazoles, pyridazine, phthalazine, triazepinone, semicarbazide, and thiomorpholide moieties and four metal complexes. These derivatives were screened against Fusarium oxysporum and the red palm weevil (RPW) Rhynchophorus ferrugineus Oliver (coleopteran: Curculionidae) as palm pathogens. Only chlorinated quinolines were active against these organisms with hydrazones being good fungicides, while those modified with pyrazoles and pyrazines showed moderate insecticidal activity. A unique trihydroxylated hydrazone was active against both organisms, while another hydrazone, the most potent fungicide in this series, exhibited insecticidal activity only upon com- plexation with Zn2+ ions.
本文描述了一系列接有腙、吡唑、哒嗪、酞嗪、三氮杂庚三酮、氨基脲和硫代吗啉部分的喹啉以及四种金属配合物的合成。针对尖孢镰刀菌和作为棕榈病原体的红棕象甲（RPW）锈色棕榈象Oliver（鞘翅目：象甲科）对这些衍生物进行了筛选。只有氯化喹啉对这些生物体有活性，其中腙是良好的杀菌剂，而那些用吡唑和吡嗪修饰的化合物表现出中等的杀虫活性。一种独特的三羟基化腙对这两种生物体都有活性，而另一种腙是该系列中最有效的杀菌剂，仅在与Zn2+离子络合时才表现出杀虫活性。
