Wang Xuefeng, Liu Mengchun, Liu Zhen, Niu Zhaoyuan, Liu Shiguo
Prenatal Diagnosis Center, Qingdao, China.
Gynecol Obstet Invest. 2015;80(3):193-8. doi: 10.1159/000377630. Epub 2015 Apr 17.
The purpose of our study was to investigate the association between polymorphism of rs2043211 in CARD8 and susceptibility to preeclampsia (PE) in the Chinese Han population.
261 PE patients and 451 controls were genotyped for rs2043211 with the method of TaqMan allele discrimination assays. Clinical data were collected to perform genotype-phenotype analysis.
Our study suggested that the rs2043211 variant was associated with the development of PE in the Chinese Han population. The genotypic and allelic frequencies differed significantly between the two groups (x03C7;2 = 8.198, p = 0.017 by genotype; x03C7;2 = 6.741, p = 0.009 by allele). The T allele was the risk allele for predisposition to PE (OR = 1.331, 95% CI 1.072-1.652).
The polymorphism of rs2043211 in CARD8 may be a relevant host susceptibility factor for the development of PE in the Chinese Han population.
本研究旨在探讨中国汉族人群中CARD8基因rs2043211多态性与子痫前期（PE）易感性之间的关联。
采用TaqMan等位基因鉴别分析方法对261例PE患者和451例对照者进行rs2043211基因分型。收集临床数据进行基因型-表型分析。
我们的研究表明，rs2043211变异与中国汉族人群中PE的发生有关。两组之间的基因型和等位基因频率存在显著差异（基因型：χ² = 8.198，p = 0.017；等位基因：χ² = 6.741，p = 0.009）。T等位基因是PE易感性的风险等位基因（OR = 1.331，95%CI 1.072 - 1.652）。
CARD8基因rs2043211多态性可能是中国汉族人群中PE发生的一个相关宿主易感因素。
