Women's Health and HIV Research Group, Department of Obstetrics and Gynaecology, University of KwaZulu-Natal, P Bag 7, Congella, KwaZulu-Natal, 4013, South Africa.
Optics and Imaging Centre, University of KwaZulu-Natal, KwaZulu-Natal, South Africa.
Curr Hypertens Rep. 2018 Aug 29;20(10):91. doi: 10.1007/s11906-018-0891-x.
Regardless of the familial linkage reported in pre-eclampsia development, understanding the polymorphic genes associated with pre-eclampsia remains limited. Hence, this review aims to outline the main genetic factors that have been investigated in respect to pre-eclampsia development.
It is apparent that different genes show significance in varying populations. Notably, it is reported that apolipoprotein-1 gene polymorphisms are associated with pre-eclampsia development in an African-American population, which may be worthwhile to investigate in a Black South African cohort. Despite the research attention that is focused on this surreptitious syndrome, a definitive cause eludes scientists and physicians, alike. Genetic studies can fulfil a dual purpose of suggesting novel hypotheses through genome-wide screening and testing these hypotheses via candidate gene studies. However, publications to date have only presented inconsistent and conflicting results regarding candidate gene analysis.
尽管子痫前期发展中有家族关联性的报道，但对与子痫前期相关的多态性基因的了解仍然有限。因此，本综述旨在概述主要遗传因子与子痫前期发展的关系。
不同基因在不同人群中的作用显著，这是显而易见的。值得注意的是，有报道称载脂蛋白-1 基因多态性与非裔美国人的子痫前期发展有关，这在南非黑人队列中值得进一步研究。尽管对这种隐匿性综合征的研究关注颇多，但科学家和医生都未能确定其确切病因。遗传研究可以通过全基因组筛查提出新的假说，并通过候选基因研究来检验这些假说，从而起到双重作用。然而，迄今为止的出版物在候选基因分析方面仅呈现出不一致和相互矛盾的结果。
