Bertino Giulia, Degiorgi Giulia, Tinelli Carmine, Cacciola Salvatore, Occhini Antonio, Benazzo Marco
Department of Otorhinolaryngology, Head and Neck Surgery, IRCCS Policlinico S. Matteo Foundation, University of Pavia, P.le Golgi 2, 27100, Pavia, Italy.
Eur Arch Otorhinolaryngol. 2015 Sep;272(9):2389-95. doi: 10.1007/s00405-015-3629-2. Epub 2015 Apr 21.
The purpose of this study was to assess the validity of CO2 laser cordectomy in the treatment of early glottic cancer and to determine the impact of margin status on disease-free survival and of the operation on voice quality. This is a retrospective review of 169 patients. Quantitative and qualitative variables were statistically compared. The impact on overall and disease-free survivals of different variables was calculated by univariate and multivariate analyses. Ten-year overall and disease free-survivals were 75 % and 60 %, respectively. Age and clinical stage showed a significant negative impact on overall survival, while margin status both on overall and disease-free survivals. The degree of dysphonia was directly related to the extension of the resection. This series confirms the good oncologic and functional outcomes of laser surgery for Tis, T1 and selected T2 glottic tumors. Patients with positive margins should undergo a further treatment or a very close follow-up.
本研究的目的是评估二氧化碳激光声带切除术治疗早期声门癌的有效性，并确定切缘状态对无病生存率的影响以及手术对嗓音质量的影响。这是一项对169例患者的回顾性研究。对定量和定性变量进行了统计学比较。通过单因素和多因素分析计算不同变量对总生存率和无病生存率的影响。10年总生存率和无病生存率分别为75%和60%。年龄和临床分期对总生存率有显著负面影响，而切缘状态对总生存率和无病生存率均有影响。发音困难的程度与切除范围直接相关。本系列研究证实了激光手术治疗Tis、T1和部分T2声门肿瘤具有良好的肿瘤学和功能学效果。切缘阳性的患者应接受进一步治疗或密切随访。
