Department of Otorhinolaryngology - Head and Neck Surgery, University of Brescia, Brescia, Italy.
Head Neck. 2010 Aug;32(8):977-83. doi: 10.1002/hed.21278.
Transoral CO(2) laser surgery has been accepted as a valuable therapeutic option for glottic cancer.
This was a retrospective analysis of 595 patients. Five-year overall and disease-specific survivals, local control with laser, locoregional, regional control, and organ preservation rates were calculated. The impact of different variables was calculated by univariate analysis.
Overall, disease-specific and disease-free survivals, local control with laser, locoregional, regional control, and organ preservation rates were 87.5%, 99%, 81.3%, 92.7%, 98.9%, 98.2%, and 97.1%, respectively. Univariate analysis showed a significant impact of pT category on local control with laser, organ preservation, locoregional and regional control, of endoscopic re-treatment for positive deep surgical margins on local control with laser and organ preservation, and recurrence after endoscopic re-treatment on local control with laser and organ preservation.
This series confirms the good oncologic outcomes of endoscopic laser surgery for T(is), T(1), and selected T(2) and T(3) glottic tumors.
经口 CO2 激光手术已被接受为治疗声门癌的一种有价值的治疗选择。
这是对 595 例患者的回顾性分析。计算了 5 年总生存率、疾病特异性生存率、激光局部控制率、局部区域控制率、区域控制率和器官保留率。通过单因素分析计算了不同变量的影响。
总体而言，总生存率、疾病特异性生存率、无病生存率、激光局部控制率、局部区域控制率、区域控制率和器官保留率分别为 87.5%、99%、81.3%、92.7%、98.9%、98.2%和 97.1%。单因素分析显示，pT 分期对激光局部控制、器官保留、局部区域和区域控制有显著影响，内镜下再次治疗阳性切缘对激光局部控制和器官保留有显著影响，内镜下再次治疗后的复发对激光局部控制和器官保留也有显著影响。
本系列研究证实了内镜激光手术治疗 T(is)、T1 和部分 T2 和 T3 声门肿瘤的良好肿瘤学结果。
